TUMORS UNDERGOING REJECTION INDUCED BY MONOCLONAL-ANTIBODIES OF THE IGG2A ISOTYPE CONTAIN INCREASED NUMBERS OF MACROPHAGES ACTIVATED FOR A DISTINCTIVE FORM OF ANTIBODY-DEPENDENT CYTOLYSIS
TUMORS UNDERGOING REJECTION INDUCED BY MONOCLONAL-ANTIBODIES OF THE IGG2A ISOTYPE CONTAIN INCREASED NUMBERS OF MACROPHAGES ACTIVATED FOR A DISTINCTIVE FORM OF ANTIBODY-DEPENDENT CYTOLYSIS
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DOI：
10.1073/pnas.81.11.3506
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
KOPROWSKI, H
中科院分区：
文献类型：
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作者：
ADAMS, DO;HALL, T;KOPROWSKI, H
IgG 2a同种型的单克隆抗体特异性抑制裸鼠中人肿瘤的生长;未给予抗体、给予与肿瘤细胞结合的IgG 2a同种型抗体或给予IgG 2b同种型抗体的小鼠中的肿瘤进行性生长。在本工作中，证明了给予IgG 2a抗体的小鼠的肿瘤基本上是坏死的团块，而来自对照小鼠的肿瘤是健康肿瘤细胞的薄片。与对照组相比，经处理小鼠的肿瘤含有增加数量的巨噬细胞，并且这些巨噬细胞被激活以进行依赖于IgG 2a同种型抗体的不同形式的细胞溶解。这些数据表明，肿瘤内巨噬细胞的数量和功能的变化是IgG 2a抗体介导的肿瘤破坏的主要组成部分。
Monoclonal antibodies of the IgG2a isotype specifically inhibit the growth of human tumors in nude mice; tumors in mice given no antibody, an antibody of the IgG2a isotype that does bind to the tumor cells, or an antibody of the IgG2b isotype grow progressively. In the present work it is demonstrated that tumors of mice given the IgG2a antibody are essentially masses of necrosis, while tumors from the control mice are sheets of healthy tumor cells. Tumors of the treated mice, in comparison to controls, contain an increased number of macrophages, and these macrophages are activated for a distinct form of cytolysis dependent on antibodies of the IgG2a isotype. The data suggest that changes in the number and function of intratumoral macrophages are a major component of tumor destruction mediated by IgG2a antibodies.