[Molecular mechanisms of vascular calcification].
[Molecular mechanisms of vascular calcification].
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发表时间：
2010-11
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通讯作者：
A. Shioi
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作者：
A. Shioi
血管钙化是一个类似于骨骼组织生理矿化的活跃过程。在血管平滑肌细胞的发育过程中，不仅细胞凋亡、细胞衰老和向骨软骨细胞转分化，而且弹性蛋白的变性和降解也可能起重要作用。血管钙化是动脉粥样硬化发展过程中各种钙化调节分子相互作用的结果。
Vascular calcification is an active process similar to physiological mineralization of skeletal tissues. Not only apoptosis, cellular senescence, and osteochondrogenic transdifferentiation of vascular smooth muscle cells, but also degeneration and degradation of elastin may play an important role in its developmental process. Vascular calcification is induced by the interactions among various regulatory molecules for calcification in the progression of atherosclerosis or arteriosclerosis.