Measuring duration mismatch negativity
Measuring duration mismatch negativity
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DOI：
10.1016/s1388-2457(03)00043-9
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发表时间：
2003-06-01
影响因子：
4.7
通讯作者：
Schröger, E
中科院分区：
文献类型：
--
作者：
Jacobsen, T;Schröger, E
目的：通过将事件相关电位（ERPs）与古怪块中呈现的标准刺激和偏差刺激进行比较，研究听觉感觉记忆中声音持续时间的自动比较。偏差引发错配负性（MMN）。这种方法可能会高估MMN对自动感觉记忆过程的贡献，因为不同的神经群的难解状态不同[Neuroreport 1996；7:3005；心理生理学2001;38:723]。在这里，使用不同的实验协议研究了基于记忆比较的持续时间MMN贡献。方法：采用4种阻塞条件对基于记忆比较的一阶持续时间MMN进行研究：(a)下行偏差（100 ms）；P = 0.14)， 150 ms标准；(b)反向上升偏差（150 ms）， 100 ms标准；(c)控制包括25至175毫秒之间的7个等概率持续时间；另外(d)在100 - 400毫秒之间的等可能音调。在前三种情况下，偏差、标准和对照在物理上是相同的。结果：比较偏差和对照排除了潜在的耐火效应，并证明了基于记忆比较的MMN和残余MMN的分解。在偏差标准-反向比较中也得到了真实持续时间MMN。结论：使用一个封闭的控制条件，在两个单独的古怪块中，反转偏差和标准的作用产生了相同的结果。因此，使用反向上升的偏差条件作为控制就足够了。(C) 2003年国际临床神经生理学联合会。爱尔兰爱思唯尔科学有限公司出版。版权所有。
Objective: Automatic comparisons of sound duration in auditory sensory memory are typically investigated by comparing event-related potentials (ERPs) to standard and deviant stimuli presented in oddball blocks. Deviants elicit mismatch negativity (MMN). This procedure might overestimate an MMN contribution reflecting automatic sensory memory processes because of differential states of refractoriness of respectively recruited neural populations [Neuroreport 1996;7:3005; Psychophysiology 2001;38:723]. Here, memory-comparison-based Duration MMN contributions were investigated using various experimental protocols.Methods: Memory-comparison-based first-order Duration MMN was investigated using 4 blocked conditions: (a) descending Deviant (100 ms. P = 0.14), 150 ms Standard; (b) reverse ascending Deviant (150 ms), 100 ms Standard; (c) Control comprised of 7 equiprobable durations between 25 and 175 ms; and additionally (d) equiprobable tones between 100 and 400 ms. Using the former 3 conditions, Deviants, Standards and Controls were physically identical.Results: Comparing Deviants and Controls excluded potential refractoriness effects, and a decomposition of memory-comparison-based MMN and residual MMN was demonstrated. Genuine Duration MMN was also obtained in the deviant-standard-reverse comparison.Conclusions: Using a blocked control condition yielded equivalent results to reversing the role of deviant and standard in two separate oddball blocks. Using the reverse ascending deviant condition is thus sufficient as a control. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. All rights reserved.