Associations between traffic-related black carbon exposure and attention in a prospective birth cohort of urban children.
Associations between traffic-related black carbon exposure and attention in a prospective birth cohort of urban children.
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DOI：
10.1289/ehp.1205940
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发表时间：
2013-07
影响因子：
10.4
通讯作者：
Wright RJ
中科院分区：
文献类型：
--
作者：
Chiu YH;Bellinger DC;Coull BA;Anderson S;Barber R;Wright RO;Wright RJ
背景：环境空气污染可能对儿童有神经毒性作用。研究与交通有关的空气污染和注意力领域之间联系的数据仍然很少。目的：我们在马萨诸塞州波士顿地区的一个出生队列中，对174名7-14岁儿童的交通颗粒物标志物黑碳（BC）和注意力测量值之间的关系进行了研究。方法：我们估计BC水平使用一个有效的时空土地利用回归模型的基础上居住在儿童的一生。孩子们完成了康纳的连续性能测试（CPT）测量遗漏错误，委托错误，命中反应时间（HRT），分数越高，表明错误增加或反应时间较慢。多变量调整线性回归分析用于检查BC和每个注意力结果之间的关联。结果：儿童主要是西班牙裔（56%）和白人（41%）; 53%是男孩。我们发现，较高的BC水平与增加的佣金错误和较慢的HRT之间存在正相关，调整儿童智商，年龄，性别，血铅水平，母亲教育，产前和产后烟草烟雾暴露和社区社会压力。值得注意的是，相对于中间两个四分位数，最高BC四分位数的相关性较弱，但仍为正相关。性别分层分析表明，BC和两个委员会的错误和HRT的男孩之间的统计学显着的关联，但BC是没有显着相关的任何CPT结果的女孩。结论：在这个城市儿童群体中，我们发现BC暴露与较高的佣金错误和较慢的反应时间之间存在关联。总体而言，这些关联在男孩身上比女孩更明显。
Background: Ambient air pollution may have neurotoxic effects in children. Data examining associations between traffic-related air pollution and attention domains remain sparse. Objectives: We examined associations between black carbon (BC), a marker of traffic particles, and attention measures ascertained at 7–14 years of age among 174 children in a birth cohort based in the Boston, Massachusetts, area. Methods: We estimated BC levels using a validated spatial–temporal land-use regression model based on residence during children’s lifetime. Children completed the Conner’s Continuous Performance Test (CPT) measuring omission errors, commission errors, and hit reaction time (HRT), with higher scores indicating increased errors or slower reaction time. Multivariable-adjusted linear regression analyses were used to examine associations between BC and each attention outcome. Results: Children were primarily Hispanic (56%) and Caucasian (41%); 53% were boys. We found a positive association between higher BC levels with increased commission errors and slower HRT, adjusting for child IQ, age, sex, blood lead level, maternal education, pre- and postnatal tobacco smoke exposure, and community-level social stress. Notably, the association was weaker, though still positive, for the highest BC quartile relative to the middle two quartiles. Sex-stratified analysis demonstrated statistically significant associations between BC and both commission errors and HRT in boys, but BC was not significantly associated with any of the CPT outcomes in girls. Conclusions: In this population of urban children, we found associations between BC exposure and higher commission errors and slower reaction time. These associations were overall more apparent in boys than girls.
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影响因子：
10.4
作者：
O'Neill MS;Jerrett M;Kawachi I;Levy JI;Cohen AJ;Gouveia N;Wilkinson P;Fletcher T;Cifuentes L;Schwartz J;Workshop on Air Pollution and Socioeconomic Conditions
通讯作者：
Workshop on Air Pollution and Socioeconomic Conditions
美国儿童的环境有毒物质和注意力缺陷多动障碍的暴露。
影响因子：
10.4
作者：
Braun, Joe M;Kahn, Robert S;Froehlich, Tanya;Auinger, Peggy;Lanphear, Bruce P
通讯作者：
Lanphear, Bruce P
影响因子：
10.4
作者：
Kannan S;Misra DP;Dvonch JT;Krishnakumar A
通讯作者：
Krishnakumar A
DOI：
10.1111/j.1467-9876.2007.00573.x
发表时间：
2007-01-01
影响因子：
1.6
作者：
Gryparis, Alexandros;Coull, Brent A.;Suh, Helen H.
通讯作者：
Suh, Helen H.
影响因子：
1.5
作者：
Calderon-Garciduenas, Lilian;Solt, Anna C.;Reed, William
通讯作者：
Reed, William