Large scale Biginelli reaction via water-based biphasic media: a green chemistry strategy
Large scale Biginelli reaction via water-based biphasic media: a green chemistry strategy
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DOI：
10.1016/j.tetlet.2005.01.087
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发表时间：
2005-03-14
影响因子：
1.8
通讯作者：
Mandadi, A
中科院分区：
文献类型：
--
作者：
Bose, AK;Manhas, MS;Mandadi, A
工艺开发中的一个重要阶段是目标化合物的千级规模制备。为此，已经开发了一种涉及水基两相反应介质的方法，用于大规模进行一些放热反应。该方案说明了能源效率和快速制备二氢嘧啶酮的无溶剂，绿色化学程序应用于Biginelli反应，使用对甲苯磺酸作为催化剂。(C)2005年由Elsevier Ltd.出版
An important stage in process development is kilo scale preparation of the target compound. For this reason, a procedure involving water-based biphasic reaction media has been developed for conducting some exothermic reactions on a large scale. This protocol is illustrated by the energy-efficient and rapid preparation of dihydropyrimidinones by a solvent-free, green chemistry procedure applied to the Biginelli reaction using p-toluenesulfonic acid as catalyst. (C) 2005 Published by Elsevier Ltd.