Effect of symptoms on executive function in bipolar illness
Effect of symptoms on executive function in bipolar illness
复制标题
DOI：
10.1017/s0033291703001570
复制
发表时间：
2004-07-01
影响因子：
6.9
通讯作者：
McGuire, PK
中科院分区：
文献类型：
--
作者：
Dixon, T;Kravariti, E;McGuire, PK
背景双相情感障碍患者认知功能与精神病学之间的关系尚不清楚。本研究评估了双相I型障碍躁狂、抑郁和缓解期的执行功能。任务评估语音和语义的口头流畅性，海林句子完成测试，Stroop神经心理筛选测试和认知估计测试管理躁狂（n = 15），抑郁（n = 15），缓解（n = 15）双相I型患者，和健康对照组（n = 30）。多元回归分析和协方差分析用于确定三个双相组中执行功能障碍的潜在决定因素。执行功能缺陷与躁狂状态特别相关。一般来说，躁狂症患者的表现不如缓解组和抑郁组准确，他们的表现缺陷与积极思维障碍的严重程度有关。抑郁和缓解双相组表现出较不广泛的损害模式。所有双相组在反应启动、战略思维和抑制控制方面都存在明显缺陷。双相I型障碍的执行功能缺陷在躁狂时最为明显，尤其与正式思维障碍相关。然而，反应启动，战略思维和抑制控制的缺陷可能更多地与潜在的疾病比一个特定的症状。
Background. The relationship between cognitive function and symptomatology in bipolar disorder is unclear. This study assessed executive function during the manic, depressed and remitted stages of bipolar I disorder.Method. Tasks assessing phonological and semantic verbal fluency, the Hayling Sentence Completion Test, the Stroop Neuropsychological Screening Test and the Cognitive Estimates Test were administered to manic (n = 15), depressed (n = 15), and remitted (n = 15) bipolar I patients, and to healthy controls (n = 30). Multiple regression analyses and analyses of covariance were used to identify potential determinants of executive dysfunction in the three bipolar groups.Results. Executive function deficits were particularly associated with the manic state. In general, manic patients performed less accurately than the remitted and depressed groups, and their performance deficit was related to the severity of positive thought disorder. The depressed and remitted bipolar groups showed a less widespread pattern of impairment. Deficits in response initiation, strategic thinking and inhibitory control were evident in all the bipolar groups.Conclusions. Executive function deficits in bipolar I disorder are most evident during mania, and are particularly associated with formal thought disorder. However, deficits in response initiation, strategic thinking and inhibitory control may be more related to the underlying disorder than a particular symptom profile.