Chronic circadian clock disruption induces expression of the cardiovascular risk factor plasminogen activator inhibitor-1 in mice
Chronic circadian clock disruption induces expression of the cardiovascular risk factor plasminogen activator inhibitor-1 in mice
复制标题
慢性生物钟破坏诱导小鼠心血管危险因素纤溶酶原激活物抑制剂-1 的表达
DOI：
10.1097/mbc.0b013e32835bfdf3
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ohkura N
中科院分区：
文献类型：
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作者：
Oishi K;Ohkura N
倒班工作与心血管疾病代谢风险因素增加之间的联系已被详细记录下来，尽管根本原因仍不清楚。纤溶酶原激活物抑制物-1(PAI-1)是纤溶的关键调节因子，也与心血管疾病的风险增加有关。我们研究了实验性慢性生物钟干扰对小鼠PAI-1表达的影响。小鼠暴露在慢性相变环境中，并以高脂肪/高蔗糖饮食喂养。慢性相变通过诱导PAI-1mRNA表达和降低肝脏组织型纤溶酶原激活物(TPA)mRNA表达，导致血浆PAI-1水平升高。慢性生物钟紊乱可能通过诱导肥胖者PAI-1基因的表达而诱导纤溶功能低下，增加心血管事件的风险。
Links between shift work and increases in metabolic risk factors for cardiovascular diseases have been documented in detail, although the underlying causes remain obscure. Plasminogen activator inhibitor-1 (PAI-1) is a key regulator of fibrinolysis that is also associated with an increased risk of cardiovascular diseases. We examined the effect of experimental chronic circadian clock disruption on PAI-1 expression in mice. Mice were exposed to chronic phase shifts and fed with a high-fat/high-sucrose diet. Chronic phase shifts resulted in increased plasma PAI-1 level through inducing PAI-1 mRNA expression and decreasing tissue-type plasminogen activator (tPA) mRNA expression in the liver. Chronic circadian clock disruption might induce hypofibrinolysis and increase the risk of cardiovascular events by inducing the PAI-1 gene expression in obese individuals.