The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined.
The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined.
复制标题
免疫和癌症中的 SphKs/S1P/S1PR1 轴：更多矿石待开采
DOI：
10.1186/s12957-016-0884-7
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发表时间：
2016-04-29
影响因子：
3.2
通讯作者：
Shi YH
中科院分区：
文献类型：
--
作者：
Jin L;Liu WR;Tian MX;Fan J;Shi YH
在过去的二十年里，人们开展了大量的研究来了解鞘氨醇的功能。揭示了许多传递生物大分子相关功能的途径。本文就SphKs/S1 P/S1 PR 1轴在免疫和肿瘤中的作用作一综述。最后，我们研究了靶向S1 P信号转导的新药在癌症治疗中的治疗潜力。
Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.