CIGARETTE-SMOKING AND LEVELS OF ADRENAL ANDROGENS IN POSTMENOPAUSAL WOMEN
CIGARETTE-SMOKING AND LEVELS OF ADRENAL ANDROGENS IN POSTMENOPAUSAL WOMEN
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DOI：
10.1056/nejm198806303182601
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发表时间：
1988-06-30
影响因子：
158.5
通讯作者：
BARRETTCONNOR, E
中科院分区：
文献类型：
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作者：
KHAW, KT;TAZUKE, S;BARRETTCONNOR, E
已经提出了吸烟的抗雌激素作用，主要是基于对绝经前妇女的数据。我们检查了吸烟与内源性激素水平的关系，其中233名白人，绝经后妇女60至79岁。目前的吸烟者的平均血浆水平明显高于肾上腺抑制剂硫酸盐和雄激素的平均血浆水平。吸烟者和非吸烟者的平均水平分别为3.1 .mu.mu.mol每升（116 .mu.g / deciliter）和2.3 .mu.mol每升（86 .mu.g / deciliter）（p <0.001）硫酸盐和27.8 nmol每升（每毫升797 pg）和22.5 nmol每升（每毫升643 pg）（每毫升643 pg）（p = 0.002），用于雄激素。对于这些激素，显而易见的剂量反应关系是显而易见的。平均血浆水平随着香烟的消耗而同时增加。调整年龄和人体质量指数后，激素水平的差异仍然存在。吸烟者和非吸烟者之间的平均水平，雌二醇，睾丸激素和性激素结合球蛋白没有差异。这些结果表明，至少在绝经后妇女中，与吸烟相关的乳腺癌和子宫内膜癌的风险可能降低可能不会通过较低的内源性雌激素来介导，并且它们引起了有关雄激素在老年人群中疾病机制中的作用的疑问。
An antiestrogenic effect of cigarette smoking has been suggested, principally on the basis of data on premenopausal women. We examined the relation between cigarette smoking and endogenous sex-hormone levels in a population of 233 white, postmenopausal women 60 to 79 years of age. Current cigarette smokers had significantly higher mean plasma levels of the adrenal androgens dehydroepiandrosterone sulfate and androstenedione than nonsmokers. Mean levels for smokers and nonsmokers were 3.1 .mu.mol per liter (116 .mu.g per deciliter) and 2.3 .mu.mol per liter (86 .mu.g per deciliter), respectively (P < 0.001), for dehydroepiandrosterone sulfate, and 27.8 nmol per liter (797 pg per milliliter) and 22.5 nmol per liter (643 pg per milliliter), respectively (P = 0.002), for androstenedione. A dose-response relation was apparent for these hormones; mean plasma levels increased concomitantly with cigarette consumption. The differences in hormone levels remained after adjustment for age and body-mass index. Mean levels of estrone, estradiol, testosterone, and sex-hormone-binding globulin did not differ between smokers and nonsmokers. These results suggest that the possible decreased risk of breast and endometrial cancer associated with cigarette smoking may not be mediated through lower levels of endogenous estrogen, at least in postmenopausal women, and they raise questions about the role of androgens in disease mechanisms in older populations.