Tumor-associated antigen is expressed on lymphocytes from patients with acquired immunodeficiency syndrome.
Tumor-associated antigen is expressed on lymphocytes from patients with acquired immunodeficiency syndrome.
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肿瘤相关抗原在获得性免疫缺陷综合征患者的淋巴细胞上表达。
DOI：
10.1111/1523-1747.ep12696687
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Edelson,RL
中科院分区：
文献类型：
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作者：
Berger,CL;Friedman-Kien,AE;DiFranco,M;Rehle,T;Ostreicher,R;Knobler,R;Donofrio,S;Laubenstein,LJ;Edelson,RL
单克隆抗体 BE2 可识别皮肤 T 细胞淋巴瘤患者 (CTCL) 恶性 T4+ 淋巴细胞上发现的抗原。正常外周血淋巴细胞不表达可检测水平的BE2抗原。 48% 的获得性免疫缺陷综合症 (AIDS) 患者的淋巴细胞群与单克隆抗体 BE2 发生反应。来自健康同性恋者、经典卡波西肉瘤或病毒综合征患者以及健康正常对照的外周血淋巴细胞为BE2-。双标记研究表明BE2+细胞是T淋巴细胞。这一观察结果表明，一些艾滋病患者以及CTCL患者的循环细胞表现出常见的淋巴细胞异常。
Monoclonal antibody BE2 recognizes an antigen found on malignant T4+lymphocytes from cutaneous T-cell lymphoma patients (CTCL). Normal peripheral blood lymphocytes do not express detectable levels of BE2 antigen. Forty-eight percent of patients with the acquired immunodeficiency syndrome (AIDS) had lymphocyte populations that were reactive with monoclonal antibody BE2. Peripheral blood lymphocytes from healthy homosexuals, patients with classical Kaposi's sarcoma or viral syndromes and healthy normal controls were BE2-. Double-labeling studies demonstrated that BE2+cells were T lymphocytes This observation demonstrates that some AIDS patients as well as CTCL patients have circulating cells that express a common lymphocyte abnormality.