HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity
HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity
复制标题
HMGB1 是一种先天性警报素，在肥胖症脂肪组织的慢性炎症中发挥着关键作用。
DOI：
10.1016/j.mce.2017.06.012
复制
发表时间：
2017-10-15
影响因子：
4.1
通讯作者：
Yang, Ping
中科院分区：
文献类型：
--
作者：
Zhang, Jing;Zhang, Lei;Yang, Ping
在过去的几十年里，肥胖已经成为一个迫在眉睫的全球公共卫生问题。现在已经变得明显的是，肥胖的特征在于脂肪组织中的持续和低度炎症，并且作为许多代谢紊乱如糖尿病和心血管疾病的独立危险因素。特别地，源自肥胖小鼠和人的脂肪细胞可能在应激损伤时主要坏死，导致包括高迁移率族蛋白1（HMGB 1）的细胞内容物被动释放到细胞外环境中。细胞外HMGB 1作为一种先天性警报素，刺激脂肪组织中常驻免疫细胞的激活。在激活时，这些驻留的免疫细胞主动分泌额外的HMGB 1，这反过来激活/招募额外的免疫细胞，并诱导脂肪细胞死亡。本文综述了HMGB 1在肥胖症脂肪组织慢性炎症状态的启动和维持方面的新发现，并讨论了其在临床环境中的潜在应用。(C)2017作者出版社：Elsevier爱尔兰Ltd.
Obesity has emerged as an imminent global public health concern over the past several decades. It has now become evident that obesity is characterized by the persistent and low-grade inflammation in the adipose tissue, and serves as an independent risk factor for many metabolic disorders such as diabetes and cardiovascular disease. Particularly, adipocytes originated from obese mice and humans likely predominate necrosis upon stressful insults, leading to passive release of cellular contents including the high mobility group box 1 (HMGB1) into the extracellular milieu. Extracellular HMGB1 acts as an innate alarmin to stimulate the activation of resident immune cells in the adipose tissue. Upon activation, those resident immune cells actively secrete additional HMGB1, which in turn activates/recruits additional immune cells, and induces adipocyte death. This review summarizes those novel discoveries in terms of HMGB1 in the initiation and maintenance of chronic inflammatory state in adipose tissue in obesity, and discusses its potential application in clinical settings. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.