Carcinoid Tumorlets Co-Existing with Chronic Pulmonary Inflammatory Processes: Imaging Findings and Histological Appearances.
Carcinoid Tumorlets Co-Existing with Chronic Pulmonary Inflammatory Processes: Imaging Findings and Histological Appearances.
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DOI：
10.12659/msm.926014
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发表时间：
2020-09-11
期刊：
影响因子：
--
通讯作者：
Chen R
中科院分区：
文献类型：
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作者：
Wang J;Ren S;Liu Y;Guo K;Chen X;Wang Z;Chen R
肺类癌瘤（PCT）是偶然的组织学或放射学发现，是局部神经内分泌肿瘤，其增殖与慢性肺部炎症过程相关。本研究评估了与慢性肺部炎症过程共存的 PCT 的影像学表现和组织学表现。我们对 2003 年 1 月 1 日至 2012 年 12 月 31 日期间接受术前 X 线和 CT 检查的 14 例偶然发现的 PCT 合并慢性肺部炎症过程的患者进行回顾性研究，对临床症状、X 线、CT 影像表现和组织学表现进行回顾性评估。 12 名女性和 2 名男性被发现患有 PCT，诊断时的平均年龄为 55.29±13.90 岁（范围 25-74 岁）。 14例患者中，出现咯血9例（64.3%）、咳嗽5例（35.7%）、胸痛3例（21.4%）、胸闷1例。对于大多数患者，我们在X光或CT图像上找不到任何小结节。然而，所有14例患者均发现支气管扩张（85.7％，12/14）、肺不张（57.1％，8/14）、炎症（92.8％，13/14）、结核（7.1％，1/14）和肺癌（7.1％，1/14）的间接影像学表现。 PCT 最常见于患有慢性肺部炎症过程（如支气管扩张、肺不张和炎症）的中年女性。尽管这些患者没有特定的症状或直接影像学表现，但我们的结果表明，患有支气管扩张、肺不张或反复肺部感染的患者进行 PCT 的风险增加。
Pulmonary carcinoid tumorlets (PCT) are incidental histologic or radiologic discoveries that are localized neuroendocrine tumors whose proliferation is associated with chronic pulmonary inflammatory processes. This study assessed the imaging findings and histological appearances of PCT co-existing with chronic pulmonary inflammatory processes. We performed a retrospective study of 14 patients with incidentally-found PCT with co-existing chronic pulmonary inflammatory processes who underwent preoperative X-rays and CT between 1 January 2003 and 31 December 2012. The clinical symptoms, X-rays, CT imaging findings, and histological appearances were retrospectively evaluated. Twelve women and 2 men were found to have PCT, with a mean age of 55.29±13.90 years (range 25–74 years) at diagnosis. Among these 14 patients, hemoptysis, cough, chest pain, expectoration, and chest tightness were found in 9 (64.3%), 5 (35.7%), 4 (28.6%), 3 (21.4%), and 1, respectively. For most patients, we could not find any small nodules on the X-ray or CT images. However, indirect imaging findings of bronchiectasis (85.7%, 12/14), atelectasis (57.1%, 8/14), inflammation (92.8%, 13/14), tuberculosis (7.1%, 1/14), and lung cancer (7.1%, 1/14) were found in all 14 patients. PCT occurs most commonly in middle-aged women who have chronic pulmonary inflammatory processes such as bronchiectasis, atelectasis, and inflammation. Although there are no specific symptoms or direct imaging findings in these patients, our results showed that patients who have bronchiectasis, atelectasis, or recurrent pulmonary infection are at increased risk for PCT.