The Association between Obesity and Cancer Risk: A Meta-Analysis of Observational Studies from 1985 to 2011.
The Association between Obesity and Cancer Risk: A Meta-Analysis of Observational Studies from 1985 to 2011.
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DOI：
10.5402/2013/680536
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Choi BC
中科院分区：
文献类型：
--
作者：
Dobbins M;Decorby K;Choi BC
背景癌症和心血管疾病是全世界死亡率和发病率的主要原因。这项荟萃分析的目的是综合评估肥胖和13种癌症之间的关联的证据，这些癌症之前被证明与肥胖显著相关。方法.本文件包括以前进行的审查的相关文件。此外，Medline和Embase的数据库检索识别出了自上次综述检索日期（2007年1月）至2011年5月期间发表的研究。筛选相关研究和系统综述的参考文献列表，以确定其他研究。每项研究的相关性评估、质量评估和数据提取由两名评价者独立进行。采用DerSimonian和Laird随机效应模型分别对男性和女性进行荟萃分析。结果从1985年到2011年，在18个国家进行了98项研究。完成了57项被判定为具有强和中等方法学质量的研究的数据提取。结果表明，肥胖男性患结肠癌（风险比（RR），1.57），肾癌（1.57），胆囊癌（1.47），胰腺癌（1.36）和恶性黑色素瘤（1.26）的风险较高。肥胖妇女患食管腺癌（2.04）、子宫内膜癌（1.85）、胆囊癌（1.82）、肾癌（1.72）、胰腺癌（1.34）、白血病（1.32）、绝经后乳腺癌（1.25）和结肠癌（1.19）的风险较高。结论.这项荟萃分析的结果表明，肥胖和癌症发病率之间存在显著的、积极的、对于某些癌症来说是强相关的。鉴于大约23%的加拿大人肥胖，如果消除或显著减少肥胖，加拿大很大一部分癌症可以避免。
Background. Cancer and cardiovascular diseases are the leading causes of mortality and morbidity worldwide. The purpose of this meta-analysis is to synthesize the evidence evaluating the association between obesity and 13 cancers shown previously to be significantly associated with obesity. Methods. Relevant papers from a previously conducted review were included in this paper. In addition, database searches of Medline and Embase identified studies published from the date of the search conducted for the previous review (January, 2007) until May, 2011. The reference lists of relevant studies and systematic reviews were screened to identify additional studies. Relevance assessment, quality assessment, and data extraction for each study were conducted by two reviewers independently. Meta-analysis was performed for men and women separately using DerSimonian and Laird's random effects model. Results. A total of 98 studies conducted in 18 countries from 1985 to 2011 were included. Data extraction was completed on the 57 studies judged to be of strong and moderate methodological quality. Results illustrated that obese men were at higher risk for developing colon (Risk Ratio (RR), 1.57), renal (1.57), gallbladder (1.47), pancreatic (1.36), and malignant melanoma cancers (1.26). Obese women were at higher risk for esophageal adenocarcinoma (2.04), endometrial (1.85), gallbladder (1.82), renal (1.72), pancreatic (1.34), leukemia (1.32), postmenopausal breast (1.25), and colon cancers (1.19). Conclusions. The results of this meta-analysis illustrate a significant, positive, and, for some cancers, strong association between obesity and cancer incidence. Given that approximately 23% of Canadians are obese, a significant proportion of cancer in Canada could be avoided if obesity was eliminated or significantly reduced.