Pancreatic Intraepithelial neoplasia
Pancreatic Intraepithelial neoplasia
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DOI：
10.1097/00006676-200404000-00008
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发表时间：
2004-04-01
期刊：
影响因子：
2.9
通讯作者：
Tanigawa, N
中科院分区：
文献类型：
--
作者：
Takaori, K;Hruban, RH;Tanigawa, N
人们致力于检测胰腺导管癌的浸润前前兆，以期改善目前浸润性胰腺癌的黯淡预后。对胰腺的深入研究已经识别出导管内乳头状粘液性肿瘤（IPMN）并检测出传统导管癌的浸润前癌前病变。导管癌前驱病变的胰腺上皮内瘤变（PanIN）命名法是1999年在美国举行的“胰腺癌智库”制定的。然而，一些前驱病变的报道表明，这些定义并没有涵盖导管癌前驱病变的全部范围，这些问题是2002年在日本举行的“胰腺原位癌论坛”的主题。经过这次论坛，人们清楚地认识到， PanIN 的现有定义需要修订和扩展。 2003年，胰腺癌智库和论坛的参与者齐聚一堂，讨论胰腺癌的前驱病变，并就PanINs和IPMNs的诊断标准达成了国际共识。我们在此描述目前对胰腺癌前驱病变的理解。
Great efforts have been devoted to detecting preinvasive precursors to ductal carcinoma of the pancreas in the hope of improving the currently bleak prognosis of invasive pancreatic cancer. Intensive investigations of the pancreas have led to the recognition of intraductal papillary mucinous neoplasms (IPMNs) and the detection of preinvasive precursors to conventional ductal carcinoma. The pancreatic intraepithelial neoplasia (PanIN) nomenclature for precursor lesions of ductal carcinoma was developed at the "Pancreatic Cancer Think Tank" held in the United States in 1999. However, some reports of precursor lesions have suggested that these definitions do not encompass the full spectrum of precursors of ductal carcinoma, and these issues were the subject of the "Forum on Carcinoma In Situ of the Pancreas" held in Japan in 2002. After this forum, it became clear that the existing definitions of PanINs needed to be revised and expanded. Both participants of the Pancreatic Cancer Think Tank and the Forum gathered together at a meeting on precursor lesions of pancreatic cancer in 2003, and an international consensus on the diagnostic criteria for PanINs and IPMNs was created. We describe herein the current understanding of precursor lesions of pancreatic cancer.