THE EFFECT OF DIETARY FATTY-ACID COMPOSITION ON LIVER RETINYL ESTER (VITAMIN-A ESTER) COMPOSITION IN THE RAT
THE EFFECT OF DIETARY FATTY-ACID COMPOSITION ON LIVER RETINYL ESTER (VITAMIN-A ESTER) COMPOSITION IN THE RAT
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DOI：
10.1093/jn/119.4.581
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发表时间：
1989-04-01
影响因子：
4.2
通讯作者：
OLSON, JA
中科院分区：
文献类型：
--
作者：
FURR, HC;CLIFFORD, AJ;OLSON, JA
本文研究了大鼠肝脏视黄酯（维生素A酯）组成对膳食脂肪酸组成的依赖性。在初始1周稳定期后，对断奶雄性Sprague-Dawley大鼠饲喂含有8%的10种试验甘油三酯（三丁酸甘油酯、三己酸甘油酯、三辛酸甘油酯、三辛酸甘油酯、三月桂酸甘油酯、三肉豆蔻酸甘油酯、三棕榈酸甘油酯、三硬脂酸甘油酯、三油酸甘油酯、三亚油酸甘油酯）或玉米油（混合甘油三酯）之一的纯化试验饲料23天。必需脂肪酸由红花油（8 g/kg饲料）提供。总肝脏脂肪酸组成显示出对膳食脂肪酸摄入的预期反应;短链和中链脂肪酸容易延长为棕榈酸酯和硬脂酸酯，棕榈酸酯和硬脂酸酯容易去饱和。油酸或亚油酸（作为其甘油三酯）的消耗显着丰富其在肝脏脂质中的浓度。棕榈酸在肝脏视黄酯中所占的比例普遍高于总脂肪酸，油酸所占的比例则较低，但视黄酯的组成受饲料甘油三酯的影响显著，尤其是长链脂肪酸的影响。总肝脏维生素A水平在喂食三亚油酸甘油酯的组中被抑制。
The dependence of liver retinyl ester (vitamin A ester) composition on dietary fatty acid composition was studied in rats. Weanling male Sprague-Dawley rats were fed purified test diets containing 8% of one of 10 test triglycerides (either tributyrin, tricaproin, tricaprylin, tricaprin, trilaurin, trimyristin, tripalmitin, tristearin, triolein, trilinolein) or corn oil (a mixed triglyceride) for 23 d after an initial 1-wk stabilization period. Essential fatty acids were provided by safflower oil (8 g/kg diet). Total liver fatty acid composition showed the expected responses to dietary fatty acid intake; short-chain and medium-chain fatty acids were readily elongated to palmitate and stearate, and palmitate and stearate were readily desaturated. Consumption of oleate or linoleate (as their triglycerides) markedly enriched their concentrations in liver lipids. The proportions of palmitate were generally greater in liver retinyl esters than in total liver fatty acids, and the proportions of oleate were less. However, retinyl ester composition was significantly affected by dietary triglyceride, particularly by diets providing long-chain fatty acids. Total liver vitamin A levels were depressed in the group fed trilinolein.