Hippocampal and neocortical gamma oscillations predict memory formation in humans
Hippocampal and neocortical gamma oscillations predict memory formation in humans
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DOI：
10.1093/cercor/bhl030
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发表时间：
2007-05-01
期刊：
影响因子：
3.7
通讯作者：
Kahana, Michael J.
中科院分区：
文献类型：
--
作者：
Sederberg, Per B.;Schulze-Bonhage, Andreas;Kahana, Michael J.
人类大脑的功能磁共振成像(FMRI)显示，海马体以及左侧的颞叶和额叶皮质在形成新的语言记忆中起着关键作用。我们记录了2349例癫痫患者在手术中植入的颅内电极的电活动，同时他们研究并回忆了常见单词的列表。使用这些记录，我们证明了海马体以及左侧颞叶和额叶皮质中的伽马振荡(44-赫兹)预测了新语言记忆的成功编码。这种伽马振荡的增加在其他频段是看不到的，在成功的记忆形成过程中，其活动通常会减少。这些发现确定了伽马振荡在海马体以及左侧颞叶和额叶皮质的言语记忆形成中的作用，这些区域与非侵入性fMRI记录方法所涉及的区域相同。
Functional magnetic resonance imaging (fMRI) of the human brain has shown that the hippocampus and the left temporal and frontal cortices play a key role in the formation of new verbal memories. We recorded electrical activity from 2349 surgically implanted intracranial electrodes in epilepsy patients while they studied and later recalled lists of common words. Using these recordings, we demonstrate that gamma oscillations (44-64 Hz) in the hippocampus and the left temporal and frontal cortices predict successful encoding of new verbal memories. This increase in gamma oscillations was not seen in other frequency bands, whose activity generally decreased during successful memory formation. These findings identify a role for gamma oscillations in verbal memory formation with the hippocampus and the left temporal and frontal cortices, the same regions implicated using noninvasive fMRI recording methods.