Serial interferon-? release assay in children with latent tuberculosis infection and children with tuberculosis
Serial interferon-? release assay in children with latent tuberculosis infection and children with tuberculosis
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DOI：
10.1002/ppul.21555
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发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Dodig, Slavica
中科院分区：
文献类型：
--
作者：
Nenadic, Natasa;Kirin, Branka Kristic;Dodig, Slavica
背景：干扰素- γ (ifn - γ)释放试验（IGRA）用于诊断潜伏性结核感染（LTBI）和活动性结核（TB）的系列检测。本研究的目的是评估IGRA对LTBI儿童和TB儿童的诊断和治疗监测结果。接种卡介苗的儿童在治疗开始前和治疗开始后6个月进行IGRA。方法：对59例接种过卡介苗的4 ~ 18岁儿童进行活动性结核暴露调查。参与者被分为两组：第一组，LTBI患儿（N = 41），第二组，TB患儿（N = 18）。IGRA （QuantiFERON-TB金管）进行了两次，即治疗前和预防和治疗结束时。结果：1组与2组受试者治疗前后ifn - γ浓度差异无统计学意义。1组和2组治疗前后ifn - γ浓度比较差异均无统计学意义。随访期间，LTBI患儿未发生活动性结核病。此外，在患有结核病的儿童中，通过抗结核治疗，结核病的体征和症状得到改善。结论：本研究表明，无论是治疗前还是治疗结束时，LTBI和TB患儿的ifn - γ浓度均无差异。IGRA可能在很长一段时间内保持阳性。IGRA似乎不能用于监测LTBI儿童和结核病儿童的治疗。儿科肺科杂志2012；47:401 - 408。(C) 2011 Wiley期刊公司
Background: Interferon-gamma (IFN-gamma) release assay (IGRA) is used for diagnosis of latent tuberculosis infection (LTBI), and for serial testing of active tuberculosis (TB). The aim of this study was to evaluate the results of IGRA for diagnosis and treatment monitoring of children with LTBI and children with TB. IGRA was performed in BCG vaccinated children before and six months after the beginning of treatment. Methods: A total of 59 BCG vaccinated children aged 4-18 years were investigated due to exposure to active TB. The participants were divided into two groups: Group 1, children with LTBI (N = 41), and Group 2, children with TB (N = 18). IGRA (QuantiFERON-TB Gold In-Tube) was performed twice, i.e., before treatment and at the end of prophylaxis and therapy. Results: There was no significant difference in IFN-gamma concentrations between Group 1 and Group 2 subjects either before or after the treatment. Difference between pre-treatment and post-treatment IFN-gamma concentrations compared in either Group 1 or Group 2 was not statistically significant. During follow-up, children with LTBI did not develop active TB. In addition, in children with TB, signs and symptoms of TB improved with anti-TB therapy. Conclusion: This study showed that the concentrations of IFN-gamma did not differ in children with LTBI and TB either before or at the end of treatment. IGRA may remain positive over a long period of time. It seems that IGRA is not useful for monitoring treatment of children with LTBI and children with TB. Pediatr Pulmonol. 2012; 47:401-408. (C) 2011 Wiley Periodicals, Inc.