Upper airway inflammation assessed by nasal lavage in compost workers: A relation with bio-aerosol exposure
Upper airway inflammation assessed by nasal lavage in compost workers: A relation with bio-aerosol exposure
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DOI：
10.1002/(sici)1097-0274(200005)37:5
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发表时间：
2000-05-01
影响因子：
3.5
通讯作者：
Heederik, D
中科院分区：
文献类型：
--
作者：
Douwes, J;Wouters, I;Heederik, D
背景在堆肥工业中暴露于微生物制剂可能导致与工作相关的气道炎症。鼻腔灌洗（NAL）已被提出作为一种非侵入性的方法，以评估这种影响在人口study.Methods前和后转移NAL进行了访问的堆肥厂在1995年（n = 14）和1996年（n = 15），其中只有4人参加了这两项调查的工人。在NAL流体中测量总细胞、细胞因子和其他炎症标志物，并且将转移前水平和后/前浓度比分别与在10个和9个对照中相同时期获得的NAL结果进行比较，并且与空气中暴露于微生物剂内毒素和β（1，结果在第一次调查中，职业暴露水平从75到527 EU/m3不等对于内毒素，β（1，3）-葡聚糖为0.54 - 4.85 μ g/m3。在第二次调查中，这些值分别较低，为29-285 EU/m3和0.36-4.44 μ g/m3。在第一次调查中，堆肥工人的总细胞、MPO、IL-8、NO和白蛋白的转移前NAL浓度显著高于对照组（1.1-4.8倍）。后/前比率的各种标记显着（1.2-3.2倍）更高的堆肥工人在这两项调查。NAL细胞主要是中性粒细胞，而嗜酸性粒细胞只是偶然观察到。暴露的MPO，尿酸肛门尿素在第一次surveillance.Conclusion职业暴露的堆肥工人可能会导致急性和可能的（亚）慢性炎症反应，在上呼吸道，推测引起的非过敏性促炎剂，如内毒素和β（1，3）-葡聚糖前班水平的弱关系。Am. J.Ind.Med.37：459-468，2000。(C)2000 Wiley-Liss，Inc.
Background Exposure to microbial agents in the composting industry may cause work related airway inflammation. Nasal lavage (NAL) has been proposed as a noninvasive method to assess such effects in population studies.Methods Pre- and post-shift NAL were performed in the workers of a compost plant visited in 1995 (n = 14) and 1996 (n = 15), of whom only four participated in both surveys. Total cells, cytokines and other inflammation markers were measured in NAL fluid, and pre-shift levels and post/pre concentration ratios were compared with NAL results obtained in the same periods in 10 and 9 controls, respectively, and with levels of airborne exposure to microbial agents endotoxin and beta(1,3)-glucan as measured in personal air samples.Results Job-title specific exposure levels in the first survey ranged from 75 to 527 EU/m(3) for endotoxin and from 0.54 to 4.85 mu g/m(3) for beta(1, 3)-glucan. In the second survey these values were lower 29-285 EU/m(3) and 0.36-4.44 mu g/m(3) respectively. In the first survey pre-shift NAL concentrations of total cells, MPO, IL-8, NO and albumin were significantly (1.1-4.8 fold) higher in compost workers than in controls. Post/pre ratios for various markers were significantly (1.2-3.2 fold) higher in compost workers in both surveys. NAL cells were mainly neutrophils, while eosinophils were only incidentally observed. A weak relation with exposure was found for pre-shift levels of MPO, uric acid anal urea in the first survey.Conclusion Occupational exposure of compost workers may cause acute and possibly (sub-)chronic inflammatory reactions in the upper airways, presumably induced by non-allergenic pro-inflammatory agents like endotoxins and beta(1,3)-glucans. Am. J. Ind. Med. 37:459-468, 2000. (C) 2000 Wiley-Liss, Inc.