Development of an in vitro microtest to assess drug susceptibility of Babesia bovis and Babesia bigemina.
Development of an in vitro microtest to assess drug susceptibility of Babesia bovis and Babesia bigemina.
复制标题
开发体外微量测试来评估牛巴贝虫和二联巴贝虫的药物敏感性。
DOI：
10.2307/3282755
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
P. Tan
中科院分区：
文献类型：
--
作者：
C. Brockelman;P. Tan
Continuous cultivation of the bovine hemoparasites Babesia bovis and Babesia bigemina was developed as an in vitro microtest to assess parasite susceptibility to babesicidal compounds. Reproducibility of parasite multiplication rates was independent of culture size, making it possible to use a microscale of 100 microliters for each test sample. Inhibitory concentrations (IC50s) of a commonly used babesicide, quinuronium sulfate, evaluated by this in vitro method were found to be 5 x 10(-8) g/ml for B. bovis and 2 x 10(-9) g/ml for B. bigemina.
