Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs
Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs
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DOI：
10.1128/aac.00903-08
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发表时间：
2008-12-01
影响因子：
4.9
通讯作者：
Jones-Brando, Lorraine
中科院分区：
文献类型：
--
作者：
Krivogorsky, Bogdana;Grundt, Peter;Jones-Brando, Lorraine
治疗弓形虫感染需要新药。我们测试了板蓝根中发现的主要成分的衍生物在体外对抗弓形虫感染的效果。靛玉红-3‘-肟类似物显示出适度的微摩尔活性，而色氨菊酯衍生物在低纳摩尔范围内显示出50%的抑制剂量。色氨菊酯具有潜在的抗弓形虫感染的作用。
New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3 '-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.