Influence of brain and azadirachtin on Trypanosoma cruzi development in the vector, Rhodnius prolixus
Influence of brain and azadirachtin on Trypanosoma cruzi development in the vector, Rhodnius prolixus
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DOI：
10.1006/expr.1998.4387
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发表时间：
1999-06-01
影响因子：
2.1
通讯作者：
Garcia, ES
中科院分区：
文献类型：
--
作者：
Gonzalez, MS;Nogueira, NFS;Garcia, ES
关于断头、头部移植、印楝素和蜕皮激素治疗对原生动物克氏锥虫载体Rhodnius prolixus中肠超微结构组织影响的研究表明，对上皮细胞组织有明显影响。当昆虫被斩首或用印楝素处理时，这些区室的超微结构组织发生显着变化，并极大地阻止了克氏锥虫感染的发展。在相反的实验中，头部移植或口服蜕皮激素疗法显着逆转了克氏锥虫的感染性，并在断头或印苦楝素处理的昆虫中重建了胃和肠的组织。这些结果表明，脑因素，可能是刺激前胸腺产生蜕皮类固醇的促前胸腺激素，可能直接或间接作用于中肠细胞组织和肠道微环境，干扰锥虫的存活和载体R prolixus的感染。 (C) 1999 年学术出版社。
Studies on the effects of decapitation, head transplantation, azadirachtin, and ecdysone therapy on the ultrastructural organization of the midgut of Rhodnius prolixus, a vector of the protozoan Trypanosoma cruzi, show a distinct effect on the organization of the epithelial cells. When insects are decapitated or treated with azadirachtin, the ultrastructural organization of these compartments changed significantly and drastically blocked the development of T. cruzi infection. In converse experiments, head transplantation or oral therapy with ecdysone significantly reversed the T. cruzi infectivity and reestablished the organization of the stomach and intestine in decapitated or azadirachtin-treated insects. These results indicat that a brain factor, possibly the prothoracicotropic hormone which stimulates ecdysteroid production on the prothoracic glands, may act directly or indirectly on both the midgut cell organization and the intestinal microenvironment interfering in the trypanosome survival and infection of the vector R prolixus. (C) 1999 Academic Press.