N-Heterocyclic Carbene-Catalyzed Cascade Reaction Involving the Hydroacylation of Unactivated Alkynes
N-Heterocyclic Carbene-Catalyzed Cascade Reaction Involving the Hydroacylation of Unactivated Alkynes
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DOI：
10.1021/ja102130s
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发表时间：
2010-05-05
影响因子：
15
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
Biju, Akkattu T.;Wurz, Nathalie E.;Glorius, Frank
报道了N-杂环卡宾（NHC）催化未活化炔的氢酰化反应，得到α，β-不饱和酮。此外，一个罕见的情况下，一个有效的和选择性的双NHC催化的级联反应，涉及炔的加氢酰化和随后的分子间Stetter反应允许形成含有1，4-二酮部分的色满酮。
The N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated alkynes to provide alpha,beta-unsaturated ketones is reported. In addition, a rare case of an efficient and selective dually NHC-catalyzed cascade reaction involving the hydroacylation of alkynes and a subsequent intermolecular Stetter reaction allows the formation of chromanones containing a 1,4-diketone moiety.