Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis.
Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis.
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DOI：
10.1007/s10620-016-4083-8
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发表时间：
2016-05
影响因子：
3.1
通讯作者：
Rinella ME
中科院分区：
文献类型：
--
作者：
Corey KE;Rinella ME
非酒精性脂肪性肝病（NAFLD）是美国最常见的肝脏疾病，在世界范围内的患病率不断上升。非酒精性脂肪性肝炎（NASH），进行性NAFLD可导致肝硬化、肝细胞癌（HCC）的发展，并需要肝移植。治疗NASH可降低疾病进展的风险。NAFLD的治疗应以减肥和运动为中心。对于NASH患者，尤其是纤维化患者，应考虑维生素E和吡格列酮的药物治疗。对于有其他手术适应症的NASH患者，减肥手术也是一种有效的治疗方法。在这篇综述中，我们将讨论目前可用的治疗NASH的方法，包括生活方式、药物和手术选择。
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in the United States with a growing prevalence worldwide. Nonalcoholic steatohepatitis (NASH), progressive form of NAFLD can lead to the development of cirrhosis, hepatocellular carcinoma (HCC), and the need for liver transplantation. Treatment of NASH may decrease the risk of progressive disease. Treatment for NAFLD should center around weight loss and exercise. Pharmacotherapy with vitamin E and pioglitazone should be considered for those with NASH, especially those with fibrosis. Weight loss surgery is also an effective treatment for NASH in individuals with other indications for surgery. In this review we will discuss the currently available therapies for NASH including lifestyle, pharmacologic and surgical options.