Transcranial Direct Current Stimulation Modulates Activation and Effective Connectivity During Spatial Navigation
Transcranial Direct Current Stimulation Modulates Activation and Effective Connectivity During Spatial Navigation
复制标题
DOI：
10.1016/j.brs.2013.12.006
复制
发表时间：
2014-03-01
影响因子：
7.7
通讯作者：
Hartley, Justin F.
中科院分区：
文献类型：
--
作者：
Hampstead, Benjamin M.;Brown, Gregory S.;Hartley, Justin F.
背景资料：以自我为中心的导航随着年龄和神经系统疾病而下降，而以自我为中心的导航则不会;差异可能源于介导空间（顶叶皮层;海马）而不是程序处理（尾状核）的大脑区域的适应不良变化。经颅直流电刺激（tDCS）的承诺，治疗这种下降的能力，以调节神经元的兴奋性，但其影响还有待研究的空间navigation.Objectives/hypotheses：使用健康的年轻人作为一个模型，研究1旨在验证一种新的空间导航范式，使用功能性磁共振成像（fMRI）。使用这些数据，以确定目标tDCS，研究2旨在确定是否1）刺激调制激活的极性特定的方式; 2）刺激结果在全球和/或任务特定的激活变化; 3）激活变化是伴随着变化的有效connections.Methods：所有参与者进行功能磁共振成像，而学习allocentric和自我中心的环境。12名参与者完成了研究1。在研究2中，16名参与者被随机分配到20分钟的tDCS（2 mA）使用蒙太奇与阳极PZ和阴极AF 4（P+F-）或反向蒙太奇（P-F+）。结果：研究1显示，不同的网络优先调解allocentric和自我中心的导航。研究2揭示了激活和连接的极性依赖性变化。P+F蒙太奇增加了这些措施的空间区域，特别是在allocentric导航，和尾状核。相反，P-F+蒙太奇增加激活和连接在外侧前额叶皮质和后hippocamps.Conclusions：这些研究结果支持tDCS在非运动区的神经调节作用，并证明了改善年龄和疾病相关的导航能力下降的原则证明。爱思唯尔公司出版
Background: Allocentric navigation declines with age and neurologic disease whereas egocentric navigation does not; differences that likely arise from maladaptive changes in brain regions mediating spatial (parietal cortex; hippocampus) but not procedural processing (caudate nucleus). Transcranial direct current stimulation (tDCS) holds promise for treating such decline given its ability to modulate neuronal excitability, but its effects have yet to be examined on spatial navigation.Objectives/hypotheses: Using healthy young adults as a model, Study 1 intended to validate a novel spatial navigation paradigm using functional magnetic resonance imaging (fMRI). Using these data to determine targets for tDCS, Study 2 aimed to determine if 1) stimulation modulates activation in a polarity-specific manner; 2) stimulation results in global and/or task-specific activation changes; 3) activation changes are accompanied by changes in effective connectivity.Methods: All participants underwent fMRI while learning allocentric and egocentric environments. Twelve participants completed Study 1. In Study 2, 16 participants were randomized to 20 min of tDCS (2 mA) using a montage with the anode over PZ and cathode over AF4 (P+F-) or the reverse montage (P-F+).Results: Study 1 revealed that distinct networks preferentially mediate allocentric and egocentric navigation. Study 2 revealed polarity-dependent changes in activation and connectivity. The P+F montage increased these measures in spatial regions, especially during allocentric navigation, and the caudate nucleus. Conversely, the P-F+ montage increased activation and connectivity in lateral prefrontal cortices and posterior hippocampus.Conclusions: These findings support the neuromodulatory effects of tDCS in non-motor areas and demonstrate proof-of-principle for ameliorating age- and disease-related decline in navigational abilities. Published by Elsevier Inc.