Guaianolides and elemanolides from Vernonia anthelmintica
Guaianolides and elemanolides from Vernonia anthelmintica
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驱虫斑鸠菊中的愈创木酚内酯和榄香脂内酯
DOI：
10.1016/j.phytol.2013.09.009
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发表时间：
2014-02-01
影响因子：
1.7
通讯作者：
Gao, Kun
中科院分区：
文献类型：
--
作者：
Zhang, Li;Shao, Yong-Liang;Gao, Kun
两个新的愈创木酚，（1 R，4 R，5S，6 R，7 R，8 S）-8，15-二羟基愈创木-10（14），11（13）-二烯-12，6-二酮（1）和（1 R，4 R，5S，6 R，7 R，8 S，11 S）-8，15-dihydroxyguaia-10（14）-en-6，12-dihydroxyguaia（2），和两种已知的榄香内酯，（4S，5 R，6 R，7 R，8 S，10 R，11 S）-11，13-dihydrovernolepin（3）和（5 R，6 R，7 R，8 S，10 R，11 S）-melitensin（4）是从驱虫斑鸠菊（Vernonia anthelmintica Willd.）通过IR、UV、MS、1D-NMR和2D-NMR等手段确定了化合物的结构，并利用CD激子手性方法和单晶X-射线衍射法确定了化合物的绝对构型。推测了化合物1-4可能的生物合成关系。评价化合物1-4对HL-60和SMMC-7721细胞系的细胞毒性。(C)2013年欧洲植物化学学会。Elsevier B. V.出版，保留所有权利。
Two new guaianolides, (1R, 4R, 5S, 6R, 7R, 8S)-8,15-dihydroxyguaia-10(14), 11(13)-dien-12,6-olide (1) and (1R, 4R, 5S, 6R, 7R, 8S, 11S)-8,15-dihydroxyguaia-10(14)-en-6,12-olide (2), and two known elemanolides, (4S, 5R, 6R, 7R, 8S, 10R, 11S)-11,13-dihydrovernolepin (3) and (5R, 6R, 7R, 8S, 10R, 11S)-melitensin (4) were isolated from the aerial parts of Vernonia anthelmintica Willd. The structures of these compounds were determined on the basis of IR, UV, MS, 1D-NMR and 2D-NMR, and their absolute configurations were deduced using the CD exciton chirality method and single-crystal X-ray diffraction. The possible biosynthetic relationships of compounds 1-4 are postulated. Compounds 1-4 were evaluated for their cytotoxicity against HL-60 and SMMC-7721 cell lines. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.