Sensory stimulation (acupuncture) increases the release of calcitonin gene-related peptide in the saliva of xerostomia sufferers
Sensory stimulation (acupuncture) increases the release of calcitonin gene-related peptide in the saliva of xerostomia sufferers
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DOI：
10.1054/npep.1999.0759
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发表时间：
1999-06-01
期刊：
影响因子：
2.9
通讯作者：
Lundeberg, T
中科院分区：
文献类型：
--
作者：
Dawidson, I;Angmar-Månsson, B;Lundeberg, T
在过去的十年中，一些患有口干症的患者接受了针灸治疗。他们的唾液流量显着增加，并且这种改善在很长的观察期内持续存在。我们还发现，针灸刺激可以增加健康受试者唾液中几种神经肽的释放。针刺治疗后口干患者唾液中血管活性肠多肽浓度显着升高。研究口干患者唾液中神经肽降钙素基因相关肽（CGRP）的释放，以进一步阐明感觉刺激（针灸）对唾液分泌的影响机制。在双系列针灸治疗之前和之后，通过放射免疫分析 (RIA) 对 14 名患有口干症的患者的刺激唾液中的 CGRP 样免疫反应性进行了测量。结果显示CGRP浓度显着升高（P
Over the last decade, several patients afflicted with xerostomia have been treated with acupuncture. Their salivary flow rates increased significantly and the improvement lasted during a long observation period. We also found that the release of several neuropeptides in the saliva of healthy subjects can be increased by acupuncture stimulation. The concentration of vasoactive intestinal polypeptide increased significantly in the saliva of xerostomic patients after acupuncture treatment. The release of the neuropeptide calcitonin gene-related peptide (CGRP) was investigated in the saliva of xerostomic patients in order to elucidate further the mechanisms of the effect of sensory stimulation (acupuncture) on the salivary secretion. CGRP-like immunoreactivity was measured with radioimmunoassay (RIA) before and after a double series of acupuncture treatment, in stimulated saliva of 14 patients who suffered from xerostomia. The results showed that the concentration of CGRP increased significantly (P