Individual histories and selection in heterogeneous populations
Individual histories and selection in heterogeneous populations
复制标题
DOI：
10.1073/pnas.0912538107
复制
发表时间：
2010-07-20
影响因子：
11.1
通讯作者：
Kussell, Edo
中科院分区：
文献类型：
--
作者：
Leibler, Stanislas;Kussell, Edo
传统上，通过测量总体种群参数（如平均繁殖率）的变化来推断种群的选择强度。将选择的影响与其他因素（如对环境波动的特定反应）分开，在微生物学和其他领域（包括癌症生物学和免疫学）都是一个重大问题，在这些领域中，选择发生在表型异质的细胞群体中。利用“个体历史”——所有繁殖事件的时间序列和个体及其祖先的表型变化——我们提出了一种在不同实验环境中量化选择的替代方法。选择被视为一个作用于历史的过程，并引入了一种利用历史分布来衡量选择的方法。我们将这一措施应用于不同进化制度中波动环境中的表型结构种群。此外，我们表明，在种群的细胞分裂树中记录的繁殖事件可能足以准确地测量选择。因此，该方法适用于广泛的生物系统，从微生物（包括基因工具尚未存在的物种）到细胞种群（如肿瘤和干细胞），在这些系统中可以获得详细的时间数据。
The strength of selection in populations has traditionally been inferred by measuring changes in bulk population parameters, such as mean reproductive rates. Untangling the effect of selection from other factors, such as specific responses to environmental fluctuations, poses a significant problem both in microbiology and in other fields, including cancer biology and immunology, where selection occurs within phenotypically heterogeneous populations of cells. Using "individual histories"-temporal sequences of all reproduction events and phenotypic changes of individuals and their ancestors-we present an alternative approach to quantifying selection in diverse experimental settings. Selection is viewed as a process that acts on histories, and a measure of selection that employs the distribution of histories is introduced. We apply this measure to phenotypically structured populations in fluctuating environments across different evolutionary regimes. Additionally, we show that reproduction events alone, recorded in the population's tree of cell divisions, may be sufficient to accurately measure selection. The measure is thus applicable in a wide range of biological systems, from microorganisms-including species for which genetic tools do not yet exist-to cellular populations, such as tumors and stem cells, where detailed temporal data are becoming available.