Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration
Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration
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DOI：
10.1002/adhm.201901321
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发表时间：
2019-11-12
影响因子：
10
通讯作者：
Parlak, Onur
中科院分区：
文献类型：
--
作者：
Keene, Scott T.;Fogarty, Daragh;Parlak, Onur
可穿戴健康监测作为标准实践的进化替代方案，能够提供快速的异地诊断和患者监测，引起了医疗保健行业的极大兴趣。特别是，基于汗液的可穿戴生物传感器提供了一种非侵入性途径，可以连续监测各种生理状况的各种生物标志物。汗液的可访问性和丰富的信息使其成为无创设备的理想目标，这些设备可以帮助疾病的早期诊断或监测运动表现。在此，首次报道了铵（NH4+）和钙（Ca2+）离子选择性膜与聚（3,4-乙烯二氧噻吩）：聚（苯乙烯磺酸）基（PEDOT：PSS）有机电化学晶体管（OECT）的集成，用于以高灵敏度和选择性对汗液中的NH4+和Ca2+进行多重传感。所提出的可穿戴汗液传感器的设计是将柔性且可拉伸的苯乙烯-乙烯-丁烯-苯乙烯基板与激光图案化的微毛细管通道阵列相结合，用于直接采集汗液并将其输送到离子选择性 OECT。由此产生的皮肤传感器具有0.01 x 10(-3) 和100 x 10(-3) m 之间的宽工作范围，完全在汗液中NH4+ 和Ca2+ 的生理水平之内。该集成设备已成功实现异位测量，并使用可穿戴传感器组件对人体进行实时分析。
Wearable health monitoring has garnered considerable interest from the healthcare industry as an evolutionary alternative to standard practices with the ability to provide rapid, off-site diagnosis and patient-monitoring. In particular, sweat-based wearable biosensors offer a noninvasive route to continuously monitor a variety of biomarkers for a range of physiological conditions. Both the accessibility and wealth of information of sweat make it an ideal target for noninvasive devices that can aid in early diagnosis of disease or to monitor athletic performance. Here, the integration of ammonium (NH4+) and calcium (Ca2+) ion-selective membranes with a poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)-based (PEDOT:PSS) organic electrochemical transistor (OECT) for multiplexed sensing of NH4+ and Ca2+ in sweat with high sensitivity and selectivity is reported for the first time. The presented wearable sweat sensor is designed by combining a flexible and stretchable styrene-ethylene-butene-styrene substrate with a laser-patterned microcapillary channel array for direct sweat acquisition and delivery to the ion-selective OECT. The resulting dermal sensor exhibits a wide working range between 0.01 x 10(-3) and 100 x 10(-3) m, well within the physiological levels of NH4+ and Ca2+ in sweat. The integrated devices are successfully implemented with both ex situ measurements and on human subjects with real-time analysis using a wearable sensor assembly.