Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse
Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse
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DOI：
10.1016/s0304-3835(00)00705-9
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发表时间：
2001-03-10
期刊：
影响因子：
9.7
通讯作者：
Cohen, LA
中科院分区：
文献类型：
--
作者：
Guttenplan, JB;Chen, M;Cohen, LA
番茄红素的摄入与前列腺癌风险降低有关。我们研究了番茄红素的作用。以两种剂量作为富含番茄红素的番茄油树脂（LTO）喂养，在前列腺中进行体内诱变。lacZ小鼠的结肠和肺。短期苯并[a]芘（BaP）诱导和长期自发诱变进行了监测。在较高剂量的LTO下观察到前列腺和结肠中自发诱变的非显著抑制，并且异常高的自发诱变率促进了结肠中抑制的观察。LTO对BaP诱发的前列腺细胞突变有轻微的抑制作用。然而，在结肠和肺中观察到BaP诱导的诱变增强。这些结果表明，LTO的任何抗突变作用可能是器官特异性的。(C)2001爱思唯尔科学爱尔兰有限公司版权所有。
Consumption of lycopene has been associated with reduced risk of prostate cancer. We have investigated the effects of lycopene. fed as a lycopene-rich tomato oleoresin (LTO) at two doses, on in vivo mutagenesis in prostate. colon, and lungs of lacZ mice. Both short-term benzo[a]pyrene (BaP)- induced and long-term spontaneous mutagenesis were monitored. Nonsignificant inhibition of spontaneous mutagenesis in prostate and colon was observed at the higher dose of LTO, and the observation of inhibition in colon was facilitated by an unusually high spontaneous mutagenesis rate. BaP-induced mutagensis was slightly inhibited by LTO in prostate. However, enhancement of BaP-induced-mutagenesis was observed in colon and Lung. These results indicate that any antimutagenic effects of LTO may be organospecific. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.