ANDROGENS AND THE EVOLUTION OF MALE-GENDER IDENTITY AMONG MALE PSEUDO-HERMAPHRODITES WITH 5-ALPHA-REDUCTASE DEFICIENCY
ANDROGENS AND THE EVOLUTION OF MALE-GENDER IDENTITY AMONG MALE PSEUDO-HERMAPHRODITES WITH 5-ALPHA-REDUCTASE DEFICIENCY
复制标题
DOI：
10.1056/nejm197905313002201
复制
发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
STURLA, E
中科院分区：
文献类型：
--
作者：
IMPERATOMCGINLEY, J;PETERSON, RE;STURLA, E
为了确定雄激素对男性性别认同形成的贡献，研究了由于5 α-睾酮导致双氢睾酮产生减少的男性假两性人。还原酶缺乏症。这些受试者出生时具有女性外观的外生殖器，并作为女孩抚养。他们的血浆睾酮水平在正常范围内，表现出对睾酮的良好反应，是评估睾酮与女性教养相比在确定性别认同方面的作用的独特模型。在38名受影响的受试者中，有18人明确地被当作女孩抚养，但在青春期或青春期之后，18人中有17人改变为男性性别身份，18人中有16人改变为男性性别角色。在子宫内、孕期和青春期，大脑暴露于正常水平的睾酮似乎对男性性别认同的形成有很大的贡献。受试者表明，在没有社会文化因素，可能会中断事件的自然顺序，睾酮的影响占主导地位，凌驾于抚养女孩的影响。
To determine the contribution of androgens to the formation of male-gender identity, male pseudohermaphrodites who had decreased dihydrotestosterone production due to 5.alpha.-reductase deficiency were studied. These subjects were born with female-appearing external genitalia and were raised as girls. They have plasma testosterone levels in the high normal range, show an excellent response to testosterone and are unique models for evaluating the effect of testosterone, as compared with a female upbringing, in determining gender identity. Of 38 affected subjects, 18 were unambiguously raised as girls, yet during or after puberty, 17 of 18 changed to a male-gender identity and 16 of 18 to a male-gender role. Exposure of the brain to normal levels of testosterone in utero, neonatally and at puberty appears to contribute substantially to the formation of male-gender identity. Subjects demonstrate that in the absence of sociocultural factors that could interrupt the natural sequence of events, the effect of testosterone predominates, over-riding the effect of rearing as girls.