Synthesis and characterization of the environmental-sensitive hyperbranched polymers as novel carriers for controlled drug release
Synthesis and characterization of the environmental-sensitive hyperbranched polymers as novel carriers for controlled drug release
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DOI：
10.1002/app.23469
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发表时间：
2006-07-05
影响因子：
3
通讯作者：
Liu, Yu-yang
中科院分区：
文献类型：
--
作者：
Hu, Hui;Fan, Xiao-Dong;Liu, Yu-yang
采用原子转移自由基聚合（ATRP）方法合成了具有环境敏感性的新型超支化聚合物，该聚合物以疏水支化聚对氯甲基苯乙烯（PCMS）为核，聚甲基丙烯酸N，N-二甲氨基乙酯（PDMA）为壳.首先，通过对氯甲基苯乙烯（CMS）的ATRP获得超支化聚合物（PCMS）核，其可以充当“引发剂”单体和引发剂。然后以前体PCMS为大分子引发剂，采用原子转移自由基聚合法合成了由PCMS和PDMA组成的不同平均臂长的改性超支化聚合物。用FTIR和H-1 NMR表征了它们的大分子结构。以苯丁酸氮芥为模型药物，研究了不同PDMA平均链长和支化度的环境敏感型超支化聚合物的药物控释行为。结果表明，pH值可以有效地控制药物的释放速率，这些环境敏感型超支化聚合物有望作为新型载体应用于药物控释系统中。(c)2006 Wiley Periodicals，Inc.
Novel hyperbranched polymers, which contain a hydrophobic branched poly(p-(chloromethy)styrene) (PCMS) core and poly(N,N-dimethylaminoethyl methacrylate) (PDMA) shell that exhibited environmental sensitivity, have been synthesized by atom transfer radical polymerization (ATRP). At first, a hyperbranched polymer (PCMS) core is obtained via ATRP of p-(chloromethy)styrene (CMS), which may act as an "inimer"-monomer and initiator. Then the modified hyperbranched polymers having different average arm length consisting of PCMS and PDMA are synthesized by ATRP using anterior PCMS as macroinitiators. Their macromolecular structures are characterized by FTIR and H-1 NMR. Using chlorambucil as a model drug, the behaviors of the controlled drug release from the environmental-sensitive hyperbranched polymers with different average chain length of PDMA and degree of branching are studied. The data demonstrate that the rate of the drug release can be effectively controlled by pH value, and these environmental-sensitive hyperbranched polymers have the potential to be used as novel carriers in some controlled drug release systems in the future. (c) 2006 Wiley Periodicals, Inc.