Histopathological study of balloon embolization: silicone versus latex.
Histopathological study of balloon embolization: silicone versus latex.
复制标题
球囊栓塞的组织病理学研究：硅胶与乳胶。
作者：
S. Miyachi;M. Negoro;T. Handa;K. Terashima;H. Keino;K. Sugita
采用吻合静脉瓣在24只杂种犬颈动脉内产生双侧对称实验性动脉瘤。用胶乳或硅胶球封堵动脉瘤两侧，2周至2个月血管造影观察。随后使用光镜和扫描电镜进行组织病理学研究。球囊栓塞后动脉瘤破裂5例；所有这些都被硅胶球囊不完全堵塞。在随后的血管造影中，发现四个硅胶球和一个乳胶球已经迁移到动脉瘤中，导致动脉瘤扩张。胶乳球囊比硅胶球囊更容易引起母动脉闭塞。组织病理学上，残余新鲜血栓，动脉瘤腔内成纤维细胞增殖减少，硅胶球囊周围存在内皮化不良。这些结果表明，由于硅胶球囊没有固定在动脉瘤内，因此动脉瘤内组织将被延迟，并且这种自由漂浮和旋转的球囊会导致动脉瘤壁的反复创伤，导致随后的动脉瘤扩大和破裂。硅胶优越的抗血栓性可能是造成这种现象偏向硅胶球囊的原因。
Bilateral, symmetrical, experimental aneurysms were produced with anastomosed vein flap in the carotid arteries of 24 mongrel dogs. Aneurysms were occluded with latex or silicone balloons on each side and observed angiographically from 2 weeks to 2 months. A histopathological study was performed subsequently using light and scanning electron microscopy. Rupture after balloon embolization occurred in five aneurysms; all of which were incompletely occluded by a silicone balloon. On subsequent angiograms, four silicone balloons and one latex balloon were found to have migrated into the aneurysm, resulting in aneurysmal expansion. Parent artery occlusion was more common with latex balloons than silicone balloons. Histopathologically, residual fresh thrombi, decreased proliferation of fibroblasts within the aneurysmal cavity, and poor endothelialization were present around the silicone balloon. These results suggest that the intra-aneurysmal organization, as seen in the aneurysm occluded by the silicone balloon, will be delayed because the balloon is not fixed within the aneurysm, and that this free-floating and rotating balloon causes repeated trauma to the aneurysm wall, contributing to subsequent enlargement and rupture of the aneurysm. The superior antithrombogenic nature of silicone may be responsible for the bias of such phenomena toward the silicone balloon.
实验性“巨型”动脉瘤的构建。
影响因子：
--
作者：
Varsos,V;Heros,RC;DeBrun,G;Zervas,NT
通讯作者：
Zervas,NT
用氰基丙烯酸异丁酯消除狗的实验性动脉瘤。
影响因子：
4.1
作者：
Debrun,GM;Varsos,V;Liszczak,TM;Davis,KR;Heros,RS;Zervas,NT
通讯作者：
Zervas,NT