Age-Associated Elongation of the Ascending Aorta in Adults
Age-Associated Elongation of the Ascending Aorta in Adults
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DOI：
10.1016/j.jcmg.2008.06.010
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发表时间：
2008-11-01
影响因子：
14
通讯作者：
Tanaka, Hirofumi
中科院分区：
文献类型：
--
作者：
Sugawara, Jun;Hayashi, Koichiro;Tanaka, Hirofumi
目的确定人的主动脉是否随年龄增长而延长，并评价假想的主动脉延长对脉搏波速度(PWV)测量的影响。背景虽然人们普遍认为随着年龄的增长，主动脉会变得弯曲，但到目前为止还没有系统的研究来确定健康成年人中是否存在这种情况。方法通过对256例19~79岁健康成人的三维横断磁共振血管描记，计算动脉长度。结果年龄越大，升主动脉越大(r=0.72)，而降主动脉、颈动脉和髂动脉长度与年龄无关。升主动脉的延长与相应的脉搏波放大指标--主动脉PWV(β=0.50)和臂动脉/主动脉脉压比(β=0.24)的增加有关。颈动脉和股动脉之间的直线距离(CAR-FEM)是最流行的动脉长度测量方法，它高估了磁共振图像测量的主动脉长度约25%。最准确的动脉长度估计是从CAR-FEM中减去颈动脉长度得到的距离，
OBJECTIVES To determine whether human aorta lengthens with aging and to evaluate the impact of the hypothesized aortic elongation on pulse wave velocity (PWV) measurements.BACKGROUND Although it is generally thought that the aorta becomes tortuous with aging, there has been no systematic study to date in healthy adults to determine if this is so. Such age-related aortic elongation may be a confounding factor for the PWV measurement in elderly people.METHODS Arterial lengths were computed by the 3-dimensional transverse magnetic resonance image arterial tracing of the aorta and carotid and iliac arteries in 256 apparently healthy adults (age 19 to 79 years).RESULTS The ascending aorta was greater with advancing age (r = 0.72), whereas the lengths of the descending aorta and carotid and iliac arteries were not associated with age. The elongation of the ascending aorta was associated with the corresponding increases in aortic PWV (beta = 0.50) and brachial/aortic pulse pressure ratio (beta = 0.24), which is an index of pulse wave amplification. The straight distance between carotid and femoral sites (car-fem), the most popular arterial length measurement, overestimated the aortic length measured with the magnetic resonance image by similar to 25%. The most accurate arterial length estimation was the distance obtained by subtracting carotid length from the car-fem, with