Effect of sun ginseng methanol extract on lipopotysaccharide-induced liver injury in rats
Effect of sun ginseng methanol extract on lipopotysaccharide-induced liver injury in rats
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DOI：
10.1016/j.phymed.2007.01.002
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发表时间：
2007-12-01
期刊：
影响因子：
7.9
通讯作者：
Yokozawa, T.
中科院分区：
文献类型：
--
作者：
Kang, K. S.;Yamabe, N.;Yokozawa, T.
太阳人参是经120℃蒸制而成的人参，其主要成分为人参皂苷-Rg(3)、-Rk(1)、-Rg(5)。本实验观察了三七总皂甙对脂多糖(LPS)诱导的大鼠肝损伤的影响。静脉注射脂多糖可引起过量的一氧化氮((NO)-N-)。并增加肝线粒体硫代巴比妥酸反应物质(TBA-RS)水平。然而，连续给药15天后，升高的TBA-RS水平显著降低。此外，给予丹参100 mg/kg体重/d可显著降低和升高内毒素处理对照组大鼠肝脏诱导型一氧化氮合酶和血红素加氧酶I的表达水平。这些抗氧化作用被认为部分与SG对核因子-kappaB的失活有关。(C)2007年爱思唯尔股份有限公司。版权所有。
Sun ginseng (SG) is heat-processed Panax ginseng C.A. MEYER steamed at 120 degrees C, which has ginsenoside-Rg(3), -Rk(1), and -Rg(5) as its main ginsenoside components. The effect of SG on lipopolysaccharide (LPS)-induced liver injury in rats was investigated in this study. Intravenous injection of LPS induced excessive nitric oxide ((NO)-N-.) generation in serum and increased the hepatic mitochondrial thiobarbituric acid-reactive substance (TBA-RS) level. However, the elevated TBA-RS level was significantly lowered by 15 consecutive days of SG administrations. In addition, up-regulated hepatic inducible nitric oxide synthase and heme oxygenase I levels in LPS-treated control rats were significantly lowered and increased, respectively, by 100mg/kg body weight/day of SG administration. These antioxidant effects were thought to be partially related to the deactivation of nuclear factor-kappa B by SG administration. (c) 2007 Elsevier GmbH. All rights reserved.