Impact of appetitive and aversive outcomes on brain responses: linking the animal and human literatures.
Impact of appetitive and aversive outcomes on brain responses: linking the animal and human literatures.
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DOI：
10.3389/fnsys.2014.00024
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发表时间：
2014
影响因子：
3
通讯作者：
Roesch MR
中科院分区：
文献类型：
--
作者：
Bissonette GB;Gentry RN;Padmala S;Pessoa L;Roesch MR
决策的动机是获得奖励和/或避免惩罚的可能性。尽管许多人研究了与食欲或厌恶结果相关的行为，但很少有人研究依赖于这两种结果的行为。很少有人解决了与预期的食欲和厌恶结果如何相互作用以改变与预期价值、动机和显着性相关的神经信号相关的问题。在这里，我们回顾了最近解决这些问题的啮齿动物、猴子和人类研究。该领域的进一步发展对于了解人类精神疾病背后的病因和开发更有效的治疗方法至关重要。
Decision-making is motivated by the possibility of obtaining reward and/or avoiding punishment. Though many have investigated behavior associated with appetitive or aversive outcomes, few have examined behaviors that rely on both. Fewer still have addressed questions related to how anticipated appetitive and aversive outcomes interact to alter neural signals related to expected value, motivation, and salience. Here we review recent rodent, monkey, and human research that address these issues. Further development of this area will be fundamental to understanding the etiology behind human psychiatric diseases and cultivating more effective treatments.