Thought suppression in patients with bipolar disorder.
Thought suppression in patients with bipolar disorder.
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双相情感障碍患者的思想抑制。
DOI：
10.1037/a0018613
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发表时间：
2010
影响因子：
4.6
通讯作者：
Williams,JMarkG
中科院分区：
文献类型：
--
作者：
Miklowitz,DavidJ;Alatiq,Yousra;Geddes,JohnR;Goodwin,GuyM;Williams,JMarkG
在实验条件下，在重性抑郁症（MDD）患者中观察到了消极思想的抑制，但从未在双相情感障碍（BD）患者中进行过检查。BD患者（n= 36），MDD患者（n= 20）和健康对照组（n= 20）完成了一项任务，要求将6个单词的字符串整理成5个单词的句子，省略1个单词。这个额外的词可以让句子以消极、中性或“过度积极”（躁狂/目标导向）的方式完成。参与者在认知负荷（排练一个6位数），奖励（铃声），负荷和奖励，或既不负荷也不奖励的条件下完成句子。我们假设BD患者比对照组更积极地抑制消极和过度积极的想法，正如他们将更多的单词串解读成消极或过度积极的句子所揭示的那样。在负荷或奖励条件下，以及在没有负荷或奖励的情况下，BD患者比对照组解读出更多的否定句。在奖励条件下，BD患者比MDD患者解读出更多的否定句。与对照组相比，BD患者还报告了更多的负面思想抑制。当当前的情绪状态得到控制时，这些负偏差的群体差异不再显著。最后，在任何条件下，两组在超肯定句子完成的比例上都没有差异。思维抑制可能为BD的心理干预提供了一个关键点。
Suppression of negative thoughts has been observed under experimental conditions among patients with major depressive disorder (MDD) but has never been examined among patients with bipolar disorder (BD). Patients with BD (n= 36), patients with MDD (n= 20), and healthy controls (n= 20) completed a task that required unscrambling 6-word strings into 5-word sentences, leaving out 1 word. The extra word allowed the sentences to be completed in a negative, neutral, or “hyperpositive”(manic/goal-oriented) way. Participants completed the sentences under conditions of cognitive load (rehearsing a 6-digit number), reward (a bell tone), load and reward, or neither load nor reward. We hypothesized that patients with BD would engage in more active suppression of negative and hyperpositive thoughts than would controls, as revealed by their unscrambling more word strings into negative or hyperpositive sentences. Under conditions of load or reward and in the absence of either load or reward, patients with BD unscrambled more negative sentences than did controls. Under conditions of reward, patients with BD unscrambled more negative sentences than did patients with MDD. Patients with BD also reported more use of negative thought suppression than did controls. These group differences in negative biases were no longer significant when current mood states were controlled. Finally, the groups did not differ in the proportion of hyperpositive sentence completions in any condition. Thought suppression may provide a critical locus for psychological interventions in BD.