Interleukin-1 genetic association with periodontitis in clinical practice
Interleukin-1 genetic association with periodontitis in clinical practice
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DOI：
10.1902/jop.2000.71.2.156
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发表时间：
2000-02-01
影响因子：
4.3
通讯作者：
Kornman, KS
中科院分区：
文献类型：
--
作者：
McDevitt, MJ;Wang, HY;Kornman, KS
背景：牙周炎是一种受多种危险因素影响的细菌性疾病。促炎细胞因子白细胞介素-1 （IL-1）是宿主对微生物感染反应的关键调节剂，也是细胞外基质分解代谢和骨吸收的主要调节剂。据报道，2号染色体上il - 1基因簇的变异与严重成人牙周炎的易感性增加有关。方法：本研究评估了复合il -1基因型（包括两个位点（IL-1A +4845 + IL-1B +3954）的等位基因2）与牙周健康到患病患者的广谱关系，这些患者通常在牙科诊所中遇到。从一家私人牙科诊所招募了90名患者，包括不吸烟者或吸烟史少于10包年（pk/yr）的前吸烟者。主要的结局变量是骨质流失，由x线片的计算机线性测量确定。使用先前报道的方法对手指棒血液样本进行基因型分析。结果：多因素logistic回归模型显示，患者年龄、既往吸烟史和IL-1基因型与成人牙周炎的严重程度显著相关。对于不吸烟者或轻度吸烟者（15 pk/年），与IL-1基因型阴性相比，IL-1基因型阳性与中度至重度牙周病的比值比增加了3.75 （95% CI: 1.04-13.50）至5.27 (95% CI: 1.23-22.70)，这取决于种族。曾经的中度吸烟者（50公斤/年）
Background: Periodontitis is a bacterial disease modified by multiple risk factors. The pro-inflammatory cytokine interleukin-l (IL-1) is a key regulator of the host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption. It has been reported that variations in the IL-I gene cluster on chromosome 2 are associated with increased susceptibility to severe adult periodontitis.Methods: The present study evaluated the association between a composite IL-l genotype, including allele 2 at each of two loci (IL-1A +4845 plus IL-1B +3954), and a broad spectrum of periodontally healthy to diseased patients in a population that is typically encountered in a dental practice setting. Ninety patients, non-smokers or former smokers with less than 10 pack-year (pk/yr) history, were recruited from a private dental practice. The major outcome variable was bone loss determined by computerized linear measurements of radiographs. Genotypes were analyzed from finger-stick blood samples using previously reported methods.Results: Multivariate logistic regression models demonstrated that patient age, former smoking history, and the IL-1 genotype were significantly associated with severity of adult periodontitis. For nonsmokers or former light smokers (15 pk/yr), IL-1 genotype positives were at increased odds ratio of having moderate to severe periodontal disease of 3.75 (95% CI: 1.04-13.50) to 5.27 (95% CI: 1.23-22.70), depending on ethnicity, compared to IL-1 genotype negatives. Former moderate smokers (>5 pk/yr and