In vivo hemodynamic performance of the Cleveland Clinic CorAide blood pump in calves.
In vivo hemodynamic performance of the Cleveland Clinic CorAide blood pump in calves.
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DOI：
10.1016/s0003-4975(01)02892-2
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发表时间：
2001-09
期刊：
影响因子：
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通讯作者：
Yoshie Ochiai;L. R. Golding;A. Massiello;A. Medvedev;R. Gerhart;Ji Feng Chen;M. Takagaki;K. Fukamachi
中科院分区：
文献类型：
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作者：
Yoshie Ochiai;L. R. Golding;A. Massiello;A. Medvedev;R. Gerhart;Ji Feng Chen;M. Takagaki;K. Fukamachi
背景Cleveland Clinic CorAide左心室辅助系统是基于一个小型可植入式连续流离心血泵，具有完全悬浮的旋转组件，用于长期循环支持方法1999年6月至2000年8月，10头犊牛植入CorAide血泵1个月，3头犊牛植入CorAide血泵3个月。min和97 ± 5 mm Hg。术后第3天的平均血浆游离血红蛋白水平为2.0 ± 1.8 mg/dL。所有病例的肾功能和肝功能均保持正常。所有病例均未发生机械故障、溶血、出血或全身器官功能障碍。尸检的重大发现仅限于两例肾梗死，其中之一是与流出道移植物infection.ConclusionsThe CorAide血泵是很容易植入，可靠的，非溶血性，和nonthrombogenic，定位它作为一个领先的第三代，连续流左心室辅助系统与一个完全悬浮转子。
BackgroundThe Cleveland Clinic CorAide left ventricular assist system is based on a small implantable continuous-flow centrifugal blood pump with a completely suspended rotating assembly designed for long-term circulatory support (5 to 10 years).MethodsBetween June 1999 and August 2000, the CorAide blood pump was implanted in 10 calves for 1 month and in 3 calves for 3 months.ResultsThe mean pump flow and arterial pressure were 6.1 ± 1.1 L/min and 97 ± 5 mm Hg, respectively. The mean plasma free-hemoglobin level after postoperative day 3 was 2.0 ± 1.8 mg/dL. Renal and hepatic function remained normal in all cases. There was no incidence of mechanical failure, hemolysis, bleeding, or systemic organ dysfunction in any of the cases. Significant findings at autopsy were limited to two cases of renal infarction, one of which was associated with an outflow graft infection.ConclusionsThe CorAide blood pump is easily implanted, reliable, nonhemolytic, and nonthrombogenic, positioning it as a leading third-generation, continuous-flow left ventricular assist system with a completely suspended rotor.