hnRNP proteins and splicing control
hnRNP proteins and splicing control
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DOI：
10.1007/978-0-387-77374-2_8
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发表时间：
2007-01-01
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影响因子：
--
通讯作者：
Chabot, Benoit
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文献类型：
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作者：
Martinez-Contreras, Rebeca;Cloutier, Philippe;Chabot, Benoit
异质核核糖核颗粒（hnRNP）家族的蛋白质形成了一组结构多样的RNA结合蛋白，涉及后生动物的各种功能。在这里，我们讨论了最近的进展，支持这些蛋白质的作用，信使RNA（前mRNA）剪接。异质核RNP蛋白可以通过直接拮抗剪接位点的识别来抑制剪接，或者可以干扰与增强子结合的蛋白质的结合。最近，hnRNP蛋白质已被证明阻碍与不同剪接位点结合的因子之间的通信。相反，一些报道已经描述了一些hnRNP蛋白在前mRNA剪接中的积极作用。此外，结合的hnRNP蛋白之间的合作相互作用可能会鼓励特定的剪接位点对之间的剪接，同时阻碍其他组合。因此，hnRNP蛋白利用多种策略来控制剪接位点选择的方式，这是重要的选择性和组成性前mRNA剪接。
Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally diverse group of RNA binding proteins implicated in various functions in metazoans. Here we discuss recent advances supporting a role for these proteins in precursor-messenger RNA (pre-mRNA) splicing. Heterogeneous nuclear RNP proteins can repress splicing by directly antagonizing the recognition of splice sites, or can interfere with the binding of proteins bound to enhancers. Recently, hnRNP proteins have been shown to hinder communication between factors bound to different splice sites. Conversely, several reports have described a positive role for some hnRNP proteins in pre-mRNA splicing. Moreover, cooperative interactions between bound hnRNP proteins may encourage splicing between specific pairs of splice sites while simultaneously hampering other combinations. Thus, hnRNP proteins utilize a variety of strategies to control splice site selection in a manner that is important for both alternative and constitutive pre-mRNA splicing.