Callistrilones A and B, Triketone-Phloroglucinol-Monoterpene Hybrids with a New Skeleton from Callistemon rigidus
Callistrilones A and B, Triketone-Phloroglucinol-Monoterpene Hybrids with a New Skeleton from Callistemon rigidus
复制标题
卡利斯三酮 A 和 B，三酮-间苯三酚-单萜杂化物，具有来自硬红千层的新骨架
DOI：
10.1021/acs.orglett.5b03360
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发表时间：
2016-01-01
期刊：
影响因子：
5.2
通讯作者：
Ye'tt, Wen-Cai
中科院分区：
文献类型：
--
作者：
Cao, Jia-Qing;Huang, Xiao-Jun;Ye'tt, Wen-Cai
The first triketone-phloroglucinol-monoterpene hybrids, callistrilones A and B (1 and 2), along with a postulated biosynthetic intermediate (3) were isolated from the leaves of Callistemon rigidus. Compounds 1 and 2 featured a new carbon skeleton with an unprecedented [1]benzofuro-[2,3-a]xanthene or [1]benzofuro[3,2-b]xanthene pentacyclic ring system composed of three kinds of building blocks. Their structures and absolute configurations were elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism (ECD) calculations. A plausible biogenetic pathway for the new compounds is also proposed. Compound 1 exhibited moderate antibacterial activity against Gram-positive bacteria including multiresistant strains.
