Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
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DOI：
10.1016/j.schres.2010.05.006
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发表时间：
2010-08-01
影响因子：
4.5
通讯作者：
Suzuki, Michio
中科院分区：
文献类型：
--
作者：
Takayanagi, Yoichiro;Takahashi, Tsutomu;Suzuki, Michio
背景：虽然临床和神经心理学研究结果表明精神分裂症中眶额皮质（OFC）的功能缺陷，但对该区域的结构磁共振成像（MRI）研究却得出了不一致的结果。此外，首发患者的 OFC 形态是否与其临床特征相关仍不清楚。方法：从 42 名（24 名男性，18 名女性）首发精神分裂症患者和 35 名（20 名男性，15 名女性）年龄、性别和父母社会经济地位 (SES) 匹配的健康受试者中获取 MR 图像。 OFC 子区域（眼眶回和直回）是在连续的 1 毫米厚的冠状切片上测量的。还对每个受试者的 OFC 脑回模式进行了评估。此外，还检查了OFC形态与临床测量之间的关系。结果：与健康受试者相比，精神分裂症患者双侧眶回的体积显着减小，而直回的体积在各组之间没有显示出差异。在精神分裂症患者中，左眶回的体积与其SES和病程呈负相关。患者和对照组右半球的 OFC 脑回模式存在显着差异。结论：本研究证明首发精神分裂症患者的 OFC 形态异常，这可能反映了疾病首发期间的神经发育畸变和神经退行性变化。我们的研究结果还表明，这种大脑结构的变化与精神分裂症中观察到的社交功能障碍有关。 (C) 2010 Elsevier B.V. 保留所有权利。
Background: Although clinical and neuropsychological findings have implicated functional deficits of the orbitofrontal cortex (OFC) in schizophrenia, structural magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings. In addition, it remains elusive whether the OFC morphology in first-episode patients is related to their clinical features.Method: MR images were acquired from 42 (24 males, 18 females) first-episode schizophrenia patients and 35 (20 males, 15 females) age-, gender-, and parental socio-economic status (SES)matched healthy subjects. The OFC sub-regions (orbital gyms and straight gyrus) were measured on contiguous 1-mm-thick coronal slices. The OFC sulco-gyral pattern was also evaluated for each subject. Furthermore, the relationships between OFC morphology and clinical measures were examined.Results: The volumes of the bilateral orbital gyri were significantly reduced in schizophrenia patients compared with healthy subjects, whereas the volumes of the straight gyri did not show differences between the groups. Among the schizophrenia patients, the volume of the left orbital gyrus was inversely correlated with their SES and illness duration. The OFC sulco-gyral patterns were significantly different between the patients and controls in the right hemisphere.Conclusion: This study demonstrated morphologic abnormalities of the OFC in first-episode schizophrenia patients, which may have reflected neurodevelopmental aberrations and neurodegenerative changes during the first episode of the illness. Our findings also suggest that such brain structural changes are related to the social dysfunction observed in schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.