In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility
In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility
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DOI：
10.1093/cercor/bhab107
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发表时间：
2021-05-06
期刊：
影响因子：
3.7
通讯作者：
Porges, E. C.
中科院分区：
文献类型：
--
作者：
Hupfeld, K. E.;Hyatt, H. W.;Porges, E. C.
大脑氧化损伤的标志物随着年龄的增长而增加。作为回应，大脑抗氧化剂水平也可能随着年龄的增长而增加，尽管这还没有得到很好的研究。在这里，我们使用编辑过的磁共振光谱来量化37名年轻人[平均值：21.8（2.5）岁; 19名女性]和23名老年人[平均值：72.8（8.9）岁; 19名女性]的内源性谷胱甘肽（GSH，最丰富的大脑抗氧化剂之一）水平。考虑到与年龄相关的萎缩，我们发现老年人的额叶和感觉运动GSH水平高于年轻人。仅对于老年人，较高的感觉运动（但不是额叶）GSH与较差的平衡和步态相关。这表明较高的脑氧化应激水平与运动表现随年龄下降之间存在区域特异性关系。我们认为这些发现反映了正常衰老时脑氧化应激增加时GSH的上调。总之，这些结果提供了对大脑抗氧化剂水平的年龄差异和对运动功能的影响的深入了解。
Brain markers of oxidative damage increase with advancing age. In response, brain antioxidant levels may also increase with age, although this has not been well investigated. Here, we used edited magnetic resonance spectroscopy to quantify endogenous levels of glutathione (GSH, one of the most abundant brain antioxidants) in 37 young [mean: 21.8 (2.5) years; 19 female] and 23 older adults [mean: 72.8 (8.9) years; 19 female]. Accounting for age-related atrophy, we identified higher frontal and sensorimotor GSH levels for the older compared with the younger adults. For the older adults only, higher sensorimotor (but not frontal) GSH was correlated with poorer balance and gait. This suggests a regionally specific relationship between higher brain oxidative stress levels and motor performance declines with age. We suggest these findings reflect an upregulation of GSH in response to increasing brain oxidative stress with normal aging. Together, these results provide insight into age differences in brain antioxidant levels and implications for motor function.