Family history and risk of atopic dermatitis in children up to 4 years
Family history and risk of atopic dermatitis in children up to 4 years
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DOI：
10.1046/j.1365-2222.2003.01749.x
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发表时间：
2003-09-01
影响因子：
6.1
通讯作者：
Wahlgren, CF
中科院分区：
文献类型：
--
作者：
Böhme, M;Wickman, M;Wahlgren, CF
背景特应性皮炎（AD）的病因可能是多因素的，遗传和环境factor.Objective之间的相互作用，以探讨特应性家族史和AD的发展之间的关系长达4 years.Methods使用年度问卷调查，我们研究了AD的累积发病率在0-4岁的前瞻性出生队列的4089。在出生时记录父母和兄弟姐妹的特应性疾病。对2614名4岁儿童的吸入性和食物过敏原的血清IgE抗体进行了分析，并将AD分为非IgE相关和IgE相关两类。结果在父母无过敏史的儿童中，27.1%发生AD，在父母有单、双亲过敏史的儿童中，分别为37.9%和50.0%。父母湿疹史和特应性呼吸道疾病（ARD）史的影响没有显着差异，也没有母亲和父亲的历史。与非IgE相关性AD相比，父母ARD病史使IgE相关性AD的风险显著增加（比值比（OR）2.0; 95%置信区间（0）1.5-2.8 vs. OR 1.3; 95% CI 1.0-1.8），而两种形式在父母湿疹的影响方面缺乏重大差异。在年长的兄弟姐妹湿疹的历史是两种形式的AD的风险指标（OR 2.1; 95%CI 1.4-3.3与OR 1.8; 95%CI 1.2-2.6）。结论我们发现母亲和父亲的特应性病史的影响之间没有差异。父母湿疹是AD的一个危险因素，无论其与IgE的关联，但父母的ARD病史主要增加IgE相关的AD的风险。
Background The aetiology of atopic dermatitis (AD) is presumably multi-factorial, with interactions between genetic and environmental factors.Objective To investigate the relation between atopic family history and development of AD up to 4 years.Methods Using annual questionnaires, we studied the cumulative incidence of AD in 0-4-year-olds in a prospective birth cohort of 4089. Atopic diseases in parents and siblings were recorded at birth. The occurrence of serum immunoglobulin E (IgE) antibodies to inhalant and food allergens was analysed in 2614 4-year-olds, and AD was divided into non-IgE-associated and IgE-associated.Results Of the children without atopic parents, 27.1% developed AD; of those with single or double parental atopic history, 37.9% and 50.0%, respectively, did so. The effects of parental history of eczema and of atopic respiratory disease (ARD) did not differ significantly, nor did those of maternal and paternal history. Parental history of ARD increased the risk significantly more for IgE-associated AD than for non-IgE-associated AD (odds ratio (OR) 2.0; 95% confidence interval (0) 1.5-2.8 vs. OR 1.3; 95% CI 1.0-1.8), whereas the two forms lacked major differences in the effect of parental eczema. A history of eczema in older siblings was a risk indicator for both forms of AD (OR 2.1; 95% CI 1.4-3.3 vs. OR 1.8; 95% CI 1.2-2.6).Conclusions We found no difference between the effects of maternal and paternal atopic history. Parental eczema was a risk factor for AD irrespective of its association with IgE, but parental history of ARD mainly increased the risk of IgE-associated AD.