The five choice serial reaction time task: Comparison between Sprague-Dawley and Long-Evans rats on acquisition of task, and sensitivity to phencyclidine
The five choice serial reaction time task: Comparison between Sprague-Dawley and Long-Evans rats on acquisition of task, and sensitivity to phencyclidine
复制标题
DOI：
10.1016/j.pbb.2009.01.005
复制
发表时间：
2009-04-01
影响因子：
3.6
通讯作者：
Depoortere, Ronan
中科院分区：
文献类型：
--
作者：
Auclair, Agnes L.;Besnard, Joel;Depoortere, Ronan
5-选择系列反应时间任务（5-CSRTT）允许测试认知/执行功能（注意力/冲动/毅力）的多个方面。然而，大多数5-CSRTT研究都是用色素大鼠（即Long-Evans: LE）进行的。白化菌株（即Sprague-Dawley: SD）更常用于行为药理学实验。因此，我们比较了SO和LE大鼠的5-CSRTT性能及其对急性苯环利定（PCP, 1-2.5 mg/kg）的敏感性。与LE大鼠相比，SD大鼠在任务习得上所需的会话（35对50）显著减少，尤其是在最短刺激光持续时间（1秒）下。然而，一旦训练。在车辆条件下，两种菌株的表现相似。相比之下，PCP处理对两种菌株的影响是不同的，因此，虽然两种菌株的准确率百分比都降低了，但SD大鼠的过早反应数量明显减少。而疏漏和纠正反应的延迟时间则明显增加。此外，PCP在SD大鼠中单调减少，但在LE大鼠的强迫反应中增强（1-1.5 mg/kg）。综上所述，在我们的实验条件下，SD菌株在获取5-CSRTT的速度上优于LE菌株。一旦训练，这两种菌株的基本性能是相当的，并且足够稳定，以应对药理化合物的挑战。然而，PCP在考虑的几个参数上对菌株的影响存在差异。(C) 2009爱思唯尔公司版权所有。
The 5-choice serial reaction time task (5-CSRTT) allows examination of multiple aspects of cognition/executive functions (attention/impulsivity/ perseveration). Most 5-CSRTT Studies are performed with pigmented (i.e. Long-Evans: LE) rats: however. albino strains (i.e. Sprague-Dawley: SD) are more commonly used in behavioural pharmacology experiments. Hence, we compared 5-CSRTT performances of SO and LE rats and their sensitivity to acute phencyclidine (PCP, 1-2.5 mg/kg). SD required significantly fewer sessions (35 Versus 50) than LE rats for task acquisition, especially at shortest stimulus light duration (1 s). However, once trained. under vehicle conditions, both strains performed similarly. In contrast, PCP treatment differentially affected the two strains, Thus, whilst percentage of accuracy was decreased for both strains, in SD rats number of premature responses was more markedly decreased. whereas omissions and latency time to correct responses were more notably increased. In addition, PCP monotonically diminished in SD, but augmented (1-1.5 mg/kg) in LE rats compulsive responding. To summarize, under our experimental conditions, the SD offer advantages over LE strain for speed of acquisition of 5-CSRTT. Once trained, basal performances of both strains were equivalent and stable enough for challenge with pharmacological Compounds. However, PCP differentially affected the strains on several parameters considered. (C) 2009 Elsevier Inc. All rights reserved.