Connectivity-Based Subdivisions of the Human Right "Temporoparietal Junction Area": Evidence for Different Areas Participating in Different Cortical Networks
Connectivity-Based Subdivisions of the Human Right "Temporoparietal Junction Area": Evidence for Different Areas Participating in Different Cortical Networks
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DOI：
10.1093/cercor/bhr268
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发表时间：
2012-08-01
期刊：
影响因子：
3.7
通讯作者：
Rushworth, Matthew F. S.
中科院分区：
文献类型：
--
作者：
Mars, Rogier B.;Sallet, Jerome;Rushworth, Matthew F. S.
围绕人脑颞顶交界区 (TPJ) 区域的作用存在争议。尽管 TPJ 与注意力和社会认知的重新定向有关，但仍不清楚这些功能是否具有相同的神经基础。事实上，TPJ 到底是一个可精确识别的皮质区域，还是一组具有独立功能的亚区域，仍然是一个有争议的问题。在这里，我们检查了TPJ的结构和功能连通性，测试TPJ是具有异质功能连通性的单一区域还是具有独特连通性的区域的聚集体。基于扩散加权成像纤维束成像的分割确定了 TPJ 中的 3 个独立区域。然后使用静息态功能连接来确定这些子区域各自参与哪些皮质网络。顶下小叶中部的背侧簇显示出与外侧前额叶皮质等区域的静息态功能连接。在腹侧，前 TPJ 簇与腹侧前额叶皮质和前岛叶相互作用，而后 TPJ 簇与后扣带回、颞极和前内侧前额叶皮质相互作用。这些结果表明，TPJ 可以根据其结构和功能连通性细分为子区域。
Controversy surrounds the role of the temporoparietal junction (TPJ) area of the human brain. Although TPJ has been implicated both in reorienting of attention and social cognition, it is still unclear whether these functions have the same neural basis. Indeed, whether TPJ is a precisely identifiable cortical region or a cluster of subregions with separate functions is still a matter of debate. Here, we examined the structural and functional connectivity of TPJ, testing whether TPJ is a unitary area with a heterogeneous functional connectivity profile or a conglomerate of regions with distinctive connectivity. Diffusion-weighted imaging tractrography-based parcellation identified 3 separate regions in TPJ. Resting-state functional connectivity was then used to establish which cortical networks each of these subregions participates in. A dorsal cluster in the middle part of the inferior parietal lobule showed resting-state functional connectivity with, among other areas, lateral anterior prefrontal cortex. Ventrally, an anterior TPJ cluster interacted with ventral prefrontal cortex and anterior insula, while a posterior TPJ cluster interacted with posterior cingulate, temporal pole, and anterior medial prefrontal cortex. These results indicate that TPJ can be subdivided into subregions on the basis of its structural and functional connectivity.