Effects of chlordecone and malnutrition on immune response in rats.
Effects of chlordecone and malnutrition on immune response in rats.
复制标题
十氯酮和营养不良对大鼠免疫反应的影响。
DOI：
10.1016/0024-3205(93)90114-i
复制
发表时间：
1993
期刊：
影响因子：
6.1
通讯作者：
Woods,L
中科院分区：
文献类型：
--
作者：
Chetty,KN;Brown,K;Walker,J;Woods,L
研究了十氯酮(Cd)和营养不良对小鼠体重、脾重量和空斑形成细胞(PFC)的影响。大鼠以正常、钙(CaD)、蛋白质(PD)或钙磷缺乏饲料喂养2~4周，饲料中镉含量分别为0、10或100ppm。用100ppm镉处理4周的营养不良大鼠死亡率高(95−100%)。经10ppm镉处理4周后，正常而非营养不良大鼠的体重略有下降，脾重量略有增加。无论是营养不良大鼠还是镉处理大鼠，PFC均显著增加。饲喂含10ppm或100ppm Cd的CaD而不是PD的大鼠的PFC也有类似的增加。然而，饲喂含100ppm Cd的Ca+P-D饮食的大鼠的PFC显著降低。
Effect of Chlordecone (Cd) and malnutrition on total body and spleen weights, and plaque forming cells (PFC) were studied. Rats were fed on normal, calcium (CaD), protein (PD) or Ca+P-deficient diets containing 0, 10 or 100 ppm of Cd for 2 or 4 weeks. High (95−100%) mortality was observed in malnourished rats treated with 100 ppm of Cd for 4 weeks. A slight decrease in body weight and an increase in spleen weight was observed in normal but not malnourished rats treated with 10 ppm of Cd for 4 weeks. PFC were significantly increased in both malnourished and Cd-treated rats. Similar increase in PFC was observed in rats fed on CaD but not PD diet containing 10 or 100 ppm of Cd. Whereas, rats fed on Ca+P-D diet containing 100 ppm of Cd exhibited a significant decrease in PFC.