Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study
Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study
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DOI：
10.1159/000285166
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Zandi, Peter P.
中科院分区：
文献类型：
--
作者：
Chuang, Yi-Fang;Hayden, Kathleen M.;Zandi, Peter P.
背景资料：APOE β 4等位基因是阿尔茨海默病的一个确定的危险因素，但其与血管性痴呆（VaD）相关的报道一直不一致。我们在1995年至2005年随访长达10年的一个大型老年人群队列中研究了APOE β 4等位基因与VaD事件风险之间的关系。方法：在基线评估时，对3,424名无痴呆的老年男性和女性进行基因分型。通过3次随访评估中执行的标准化程序确定事件风险评估。采用考克斯比例风险模型评估与APOE β 4相关的VaD风险。结果如下：具有1个APOE <$4等位基因的受试者的校正风险比为1.6（95% CI：0.9-2.7; p = 0.083），具有2个APOE <$4等位基因的受试者为4.4（95% CI：1.6-12.5; p = 0.005）。增加的风险似乎不是由血管危险因素介导的。结论：APOE β 4等位基因以剂量依赖性方式与VaD风险增加相关，占人群VaD的近20%。版权所有（C）2010 S. Karger AG，巴塞尔
Background: The APOE epsilon 4 allele is an established risk factor for Alzheimer's disease, but reports of its association with vascular dementia (VaD) have been inconsistent. We examined the relationship between APOE epsilon 4 allele and the risk of incident VaD in a large, population-based cohort of elderly adults with up to 10 years of follow-up between 1995 and 2005. Methods: A total of 3,424 elderly men and women free of dementia were genotyped at the baseline assessment. Incident VaD was identified through standardized procedures administered at 3 follow-up assessments. Cox proportional hazards models were used to evaluate the risk of VaD associated with APOE epsilon 4. Results: The adjusted hazard ratio was 1.6 for the participants with 1 APOE epsilon 4 allele (95% CI: 0.9-2.7; p = 0.083) and 4.4 for those with 2 APOE epsilon 4 alleles ( 95% CI: 1.6-12.5; p = 0.005). The increased risk did not appear to be mediated by vascular risk factors. Conclusions: The APOE epsilon 4 allele is associated with an increased risk of VaD in a dose-dependent fashion and accounts for almost 20% of VaD in the population. Copyright (C) 2010 S. Karger AG, Basel