Toxic additives in medication for preterm infants
Toxic additives in medication for preterm infants
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DOI：
10.1136/adc.2008.146035
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发表时间：
2009-07-01
影响因子：
4.4
通讯作者：
Pandya, H. C.
中科院分区：
文献类型：
--
作者：
Whittaker, A.;Currie, A. E.;Pandya, H. C.
背景：关于早产儿在常规临床护理中暴露于辅料的情况知之甚少。目的：记录单个中心脆弱早产儿的辅料暴露，将慢性肺病（CLD）作为疾病严重程度的标志。设计图：通过回顾性分析新生儿病房收治的婴儿的药物图表，确定8种口服液体药物治疗后的赋形剂暴露。设置：莱斯特新生儿服务中心。参与者：38名出生于2005年6月至2006年7月的婴儿，妊娠期小于30周，出生时体重1500 g，在莱斯特出院。结果：38名婴儿占合格目标组的53%; 7/38名婴儿患有CLD。在住院期间，婴儿暴露于20多种赋形剂，包括乙醇和丙二醇，这些化学物质与神经毒性有关。患有CLD的婴儿暴露于更高浓度的这些毒素。婴儿也暴露于高浓度的山梨糖醇，与一些婴儿暴露于浓度超过推荐的最大暴露在adult.Conclusions指南：早产儿通常暴露于赋形剂，其中一些是潜在的毒性。迫切需要减少早产儿辅料负荷的策略
Background: Little is known about exposure of preterm infants to excipients during routine clinical care. Objective: To document excipient exposure in vulnerable preterm babies in a single centre, taking into account chronic lung disease (CLD) as a marker of illness severity. Design: Excipient exposure after treatment with eight oral liquid medications was determined by retrospectively analysing the drug charts of infants admitted to a neonatal unit.Setting: The Leicester Neonatal Service.Participants: 38 infants born between June 2005 and July 2006 who were less than 30 weeks' gestation and 1500 g in weight at birth and managed in Leicester to discharge.Results: The 38 infants represented 53% of the eligible target group; 7/38 infants had CLD. During their in-patient stay, infants were exposed to over 20 excipients including ethanol and propylene glycol, chemicals associated with neurotoxicity. Infants with CLD were exposed to higher concentrations of these toxins. Infants were also exposed to high concentrations of sorbitol, with some infants being exposed to concentrations in excess of recommended guidelines for maximum exposure in adults.Conclusions: Preterm infants are commonly exposed to excipients, some of which are potentially toxic. Strategies aimed at reducing excipient load in preterm infants are urgently required