Measuring European population stratification with microarray genotype data
Measuring European population stratification with microarray genotype data
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DOI：
10.1086/513477
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发表时间：
2007-05-01
影响因子：
9.8
通讯作者：
Shriver, Mark D.
中科院分区：
文献类型：
--
作者：
Bauchet, Marc;McEvoy, Brian;Shriver, Mark D.
在试图通过关联图谱找到复杂性状的基因时，正确理解群体遗传分层--群体内个体祖先的差异--是至关重要的。我们报道了297个个体的大约10,000个单核苷酸多态的全基因组分型，以探索已知和未知血统的欧洲人的群体结构。结果揭示了几个重要的分层轴线的存在，最突出的是北-东南趋势，但也沿着东西轴线。我们还展示了欧洲血统信息标记(EuroAIMs)的选择和应用，以进行血统估计和校正。科里尔高加索人和CEPH(人类多形态中心)犹他州样本板，经常被用作欧洲人口的代理人，被发现反映了欧洲大陆祖先的不同子集。
A proper understanding of population genetic stratification - differences in individual ancestry within a population - is crucial in attempts to find genes for complex traits through association mapping. We report on genomewide typing of similar to 10,000 single-nucleotide polymorphisms in 297 individuals, to explore population structure in Europeans of known and unknown ancestry. The results reveal the presence of several significant axes of stratification, most prominently in a northern-southeastern trend, but also along an east-west axis. We also demonstrate the selection and application of EuroAIMs ( European ancestry informative markers) for ancestry estimation and correction. The Coriell Caucasian and CEPH ( Centre d'E tude du Polymorphisme Humain) Utah sample panels, often used as proxies for European populations, are found to reflect different subsets of the continent's ancestry.