MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells.
MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells.
复制标题
microRNA参与癌症干细胞的自我更新和分化。
DOI：
10.1038/aps.2013.134
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发表时间：
2013-11
影响因子：
8.2
通讯作者：
Xi, Yaguang
中科院分区：
文献类型：
--
作者：
Wang, Zheng-ming;Du, Wen-jun;Piazza, Gary A.;Xi, Yaguang
microRNA（miRNAs）是一类非编码RNA小分子，其主要功能是在转录后/翻译水平调控基因表达。miRNAs在正常的生物学过程中起着至关重要的作用，并且在人类疾病中通常失调。干细胞被认为是构成身体组织和器官的所有类型分化细胞的“母”细胞。一种新的假说提出，肿瘤是由来自癌症干细胞的异质细胞组成的，这些细胞具有与正常干细胞相似的自我更新和分化能力。癌症干细胞已从各种肿瘤中分离出来并进行了表征。鉴于最近的研究支持miRNA在癌症干细胞的自我更新和分化中的关键调节作用，更好地理解miRNA的功能将为预防肿瘤发生和肿瘤进展提供宝贵的见解。本文就miRNAs参与肿瘤干细胞自我更新和分化的研究进展作一综述。
MicroRNAs (miRNAs) are small non-coding RNA molecules, whose primary function is to regulate gene expression at the post-transcriptional/translational levels. MiRNAs play crucial roles in normal biological processes and are commonly dys-regulated in human diseases. Stem cells are regarded as the “mother” cells of all types of differentiated cells that comprise tissues and organs of the body. A novel hypothesis proposes that tumors are composed of heterogeneous cells derived from cancer stem cells, which have self-renewal and differentiation capabilities similar to those of normal stem cells. Cancer stem cells have been isolated and characterized from various tumors. Given recent studies supporting the critical regulatory roles of miRNAs in the self-renewal and differentiation of cancer stem cells, better understanding the functions of miRNAs will provide invaluable insights into the prevention of tumorigenesis and tumor progression. In this review, we will summarize the research progress in the study of miRNAs involved in the self-renewal and differentiation of cancer stem cells.
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影响因子：
10.5
作者：
Dontu, G;Abdallah, WM;Wicha, MS
通讯作者：
Wicha, MS
DOI：
10.1016/j.bbrc.2008.08.107
发表时间：
2008-11-07
影响因子：
3.1
作者：
Gal, Hilah;Pandi, Gopal;Givol, David
通讯作者：
Givol, David
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
11.2
作者：
Bracken, Cameron P.;Gregory, Philip A.;Goodall, Gregory J.
通讯作者：
Goodall, Gregory J.
影响因子：
23.9
作者：
Delaloy C;Liu L;Lee JA;Su H;Shen F;Yang GY;Young WL;Ivey KN;Gao FB
通讯作者：
Gao FB